Training Face Recognition in Adults with Prosopagnosia

脸失认症是一种无法识别面孔的疾病，是一种社交障碍。因此，培训计划 研究提高面部识别能力对于治疗这种疾病 并更好地了解人脸识别系统。然而，公开的训练尝试 人脸识别很少。本提案的主要目标是创建和评估培训 一个基于感知学习原理的项目，目标是面孔失认症患者感知的能力 面部结构我们的中心假设是，这种训练将改善行为和神经 面孔失认症患者对面孔的反应我们将研究一个相对较大的队列，并收集一个全面的 每个参与者的个人资料，包括行为和功能磁共振成像数据。这些数据将解决我们的二级 目标，这是为了确定改进的必要条件：也就是说， 面孔失认症的类型得到改善，大脑中的哪些结构可能对成功的训练至关重要。 具体目标：项目的具体目标是确定干预措施，对后天的影响 和发展性面容失认症的行为反应的面孔（目标1和3）。此外，委员会认为， 我们希望评估干预对面容失认症患者的影响，s神经反应 （目标2和4）。这些目标的实现将使我们能够，首先， 时间，直接比较获得性和发展性面孔失认症，以及阐明功能 和从培训中获益的结构性决定因素。方法：干预前基线评估 将包括面部处理和神经激活的措施。参与者将完成大约 30分钟的训练，每周3次。该培训将采用自适应阶梯方法 随着表现的提高，参与者逐渐接触到更多相似的面孔。 随着训练计划的每个阶段，表情和角度的变化程度更大， 将引入脸，以增加训练效果推广到新的后训练的可能性 刺激和现实世界的情况。将对培训前和培训后的评估进行比较，以检查改进情况 面部处理技能和神经激活的变化。此外，集团数据将 与年龄匹配的对照组相比。健康相关性：除了促进我们对 皮层人脸网络和本系统的可塑性，建议将提供一个在线训练的工作 为患有面容失认症的成年人提供的项目，将广泛提供。博士后培训计划：作为 作为培训计划的一部分，申请人将学习功能性神经成像的新技能，新方法， 和神经眼科学的观点，并将有机会广泛研究 一群患有面容失认症的成年人

Prosopagnosia, an inability to recognize faces, is a socially debilitating disorder. Therefore, training programs that investigate the ability to improve face recognition are essential for both treating the disorder and gaining a better understanding of the face recognition system. However, published attempts at training face recognition have been few. The primary goal of this proposal is to create and evaluate a training program based on perceptual learning principles that target the ability of prosopagnosic subjects to perceive facial structure. Our central hypothesis is that this training will improve behavioral and neural responses to faces in prosopagnosia. We will study a relatively large cohort and collect a comprehensive profile for each participant, including behavioral and fMRI data. These data will address our secondary goal, which is to determine the necessary conditions for improvement: that is, which functional types of prosopagnosia improve, and what structures in the brain may be critical for successful training. Specific Aims: The specific aims of the project are to determine the interventions effect on acquired and developmental prosopagnosics behavioral response to faces (aims 1 and 3). Furthermore, we hope to evaluate the effect that the intervention has on prosopagnosics neural response to faces (aims 2 and 4). The accomplishments of these aims will allow us to, for the first time, directly compare acquired and developmental prosopagnosia as well as clarify the functional and structural determinants of benefit from training. Method: Pre-intervention baseline assessments will include measures of face processing and neural activation. Participants will complete approximately 30 minutes of training, 3 times per week. This training will utilize an adaptive staircase method in which participants are gradually exposed to more similar pairs of faces as performance improves. With each phase of the training program, a greater degree of variance in expression and angle of the face will be introduced to increase the possibility that training effects will generalize to novel post-training stimuli and real-world situations. Pre- and post-training assessments will be compared to examine improvements in face processing skill and changes in neural activation. In addition, group data will be compared to age-matched controls. Health Relevance: In addition to advancing our understanding of the cortical face network and the plasticity of this system, the proposed work will provide an online training program for adults with prosopagnosia that will be widely available. Postdoctoral Training program: As part of the training program, the applicant will learn new skills in functional neuroimaging, new approaches and perspectives in neuro-ophthalmology, and will have the opportunity to extensively examine a large cohort of adults with prosopagnosia.