Prostate Cancer Detection Through Urine Headspace Analysis Using Colorimetric Sen

描述（由申请人提供）：在美国，前列腺癌是男性癌症死亡的第二大原因，六分之一的男性在其一生中最终会患上前列腺癌。目前，前列腺特异性抗原检测和直肠指检是最常用的前列腺癌检测工具，但这两种方法特异性较低，对侵袭性前列腺癌的预测能力较差。为此，研究人员和临床医生一直在努力发现新的生物标志物，以高精度地提供疾病的早期指示。iSense医疗公司开发了一种传感器平台，可以从尿液顶空的代谢组学生物标志物中识别癌症。癌细胞代谢产生独特的挥发性有机化合物，这些化合物分解到血液中，然后排泄到尿液中，可以使用我们的比色传感器阵列技术在尿液顶空中测量。在这项工作中，我们提出通过尿液顶空分析来检测前列腺癌。如果成功，该检测将提供一种非侵入性、快速（<1小时）、低成本（10美元）的即时诊断工具，用于早期检测和评估前列腺癌的侵袭性。

DESCRIPTION (provided by applicant): In the U.S., prostate cancer is the second leading cause of cancer death in men, and one in six men will eventually develop prostate cancer during his lifetime. Currently, the prostate specific antigen test and digital rectal examination are the most predominant used tools for prostate cancer detection, but both methods have low specificity and poorly predict the presence of aggressive prostate cancer. To that end, researchers and clinicians have worked to discover novel biomarkers that would give an early indication of the disease with high accuracy. iSense Medical Corp. has developed a sensor platform that enables the identification of cancer from metabolomic biomarkers in urine headspace. The cancer cell metabolism produces unique volatile organic compounds that partitions to blood and then excretes into urine, which can be measured in the urine headspace using our colorimetric sensor array technology. In this work, we propose the detection of prostate cancer from urine headspace analysis. If successful, this assay will offer a non-invasive, rapid (<1 hour), low-cost (order $10), point-of-care diagnostic tool for early detection and assessment of aggressiveness of prostate cancer.