Folate targeted intraoperative cancer imaging to guide pulmonary resections

描述（由申请人提供）：本犬临床试验的主要目的是为术中癌症检测和图像引导手术提供革命性的显像剂。在美国，每年有超过70万的癌症患者接受手术切除肿瘤。唯一最重要的患者生存预测指标是原发肿瘤的完全手术切除，引流淋巴结和转移性病变。然而，高达40%的手术患者在切除后离开手术室时仍留有恶性细胞。因此，迫切需要开发新的创新技术，帮助外科医生通过划定肿瘤边缘、识别微转移和引流淋巴结来确保肿瘤完全切除。我们提出了一种新的技术，在标准护理癌症手术结束时对患者进行成像，以便在完成手术前发现残留的局部疾病。虽然所提出的技术广泛适用于实体肿瘤，但该项目特别致力于提高肺腺癌（最具侵袭性的人类恶性肿瘤之一）的检测。所提出的工作将优化近红外叶酸靶向造影剂和转化术中成像方法。叶酸-近红外染料造影剂将在犬自发性肺癌手术模型中进行优化。

DESCRIPTION (provided by applicant): The primary goal of this pilot canine clinical trial is to translate revolutionary imaging agents for intraoperative cancer detection and image-guided surgery. Half of all cancer patients, over 700,000 annually in the US, undergo surgery to remove their tumor. The single most important predictor of patient survival is a complete surgical resection of the primary tumor, draining lymph nodes, and metastatic lesions. However, up to 40% of surgical patients leave the operating room with malignant cells remaining after resection. Thus, there are urgent unmet needs to develop new and innovative technologies that can assist the surgeon in ensuring complete tumor resection by delineating tumor margins, and identifying micrometastases and draining lymph nodes. We propose a new technology to image patients at the conclusion of the standard-of-care cancer operation in order to discover residual local disease before completing the surgery. While the proposed technologies are broadly applicable to solid tumors, this project is specifically committed to improving detection of lung adenocarcinomas, one of the most aggressive human malignancies. The proposed work will optimize a near-infrared folate targeted contrast agent and translate an intraoperative imaging approach. The folate-near infrared dye contrast agent will be optimized in a canine surgical model for spontaneous lung cancer.