Core Center for Quantitative Neuroscience with Magnetic Resonance (QNMR)

描述(申请人提供)：最先进的MRI/MRS技术是成像大脑结构和功能的最强大的活体方法之一。但由于技术和专业知识的进入成本过高，研究活体动物模型的神经科学家采用MRI/MRS的速度一直很慢。耶鲁大学的定量神经科学核磁共振(Q核磁共振)核心中心为耶鲁大学和附近机构的跨学科MR神经科学研究提供了神经科学PI的访问和支持。这些资源包括几个小的和宽的高场水平孔磁体以及射频(RF)线圈工程的相关资源，复杂手术和输液的辅助设施和技术支持，设备齐全的生化和材料科学实验室，进行体内电学和光学研究的几个神经生理学装置，先进的分布式计算和存档数据处理设施。Q核磁共振核心中心由四个协同模块组成，每个模块都致力于提高正在进行的研究的有效性，这些研究基于涉及磁共振(核心1)、磁共振波谱(核心2)、神经生理学(核心3)和数据分析(核心4)的跨学科神经科学研究。每个核心项目的目标是：(I)实施、维持和支持神经科学绩效指标的核心方法；(Ii)支持使用核心方法的新研究计划；(Iii)为神经科学绩效指标及其工作人员提供培训和指导；(Iv)整合MR/神经生理学测量和特定于PL的数据分析的协同使用；(V)实施新的支持神经科学绩效指标的核心方法；以及(Vi)跟踪核心活动并向NIH社区传播/共享资源。Q核磁共振核心中心的总体目标是通过促进神经科学家使用先进的磁共振和磁共振/电学/光学相结合的方法，以及通过向整个NIH社区传播发现和改进的方法，来加强NINDS和NIH资助的研究。

DESCRIPTION (provided by applicant): State-of-the-art MRI/MRS techniques are among the most powerful in vivo methods for imaging brain Structure and function. But adoption of MRI/MRS by neuroscientists working with in vivo animal models has been slow due to excessive entry costs of technology and expertise. Yale's Quantitative Neuroscience with Magnetic Resonance (QNMR) Core Center provides access and support to neuroscience PIs, at Yale and nearby institutions, for cross-disciplinary MR-based neuroscience studies. The resources include several high-field, both small and wide, horizontal-bore magnets as well as related resources for radio-frequency (RF) coil engineering, auxiliary facilities and technical support for complex surgeries and infusions, fully equipped biochemical and material science laboratories, several neurophysiological rigs to conduct in vivo electrical and optical studies, an advanced data processing facilities with distributed computing and archiving. The QNMR Core Center consists of four synergistic modules, each dedicated to improving effectiveness of ongoing research based upon cross-disciplinary neuroscience studies involving MRI (Core 1), MRS (Core 2), neurophysiology (Core 3), and data analysis (Core 4). The aims for each Core are to (i) implement, maintain, and support the Core methods for neuroscience PIs; (ii) support new research initiatives using Core methods; (iii) train and provide mentorship for neuroscience PIs and their staff; (iv) integrate synergistic use of MR/neurophysiological measurements and Pl-specific data analysis; (v) implement new Core methods to support neuroscience PIs; and (vi) track Core activities and disseminate/share resources to NIH community. The overall goal of the QNMR Core Center is to enhance NINDS- and NIH-funded research through facilitating the use of neuroscientists of advanced MR and combined MR/electrical/optical methods and through dissemination of discoveries and improved methodologies to the NIH community at large.