Training in the Science of Co-Occurring Disorders

描述（由申请人提供）：该提案将在跨学科研究，共同发生的物质使用和其他精神障碍（COD）的发展领域建立一个独特的培训计划。考虑到COD在成瘾性疾病患者中更常见，而不是例外，因此对这一科学重点的需求至关重要。该计划的哲学主张，要有效地影响成瘾和精神疾病的问题，必须充分意识到它们的共存，病因，现象学和临床表现。此外，为成瘾和精神疾病患者提供服务的临床方法和医疗保健系统的知识对于告知实验室和临床研究中要提出的问题是必要的。将COD作为主要观点并不是一种被广泛接受的科学家培训方法。在NIDA的大约60个T32项目中，没有一个包括合并症、双重诊断或其他关注COD的指标。建立优先考虑这一领域培训的计划将导致开发先进的方法，以找到为COD患者服务的创新战略。我们建议通过利用达特茅斯独特的资源和机会来开发这样一个项目。六个相互关联的小组将提供社会，行为和神经生物学机制，治疗开发（心理和药理学），技术辅助治疗和传播以及卫生服务实践和实施的研究机会。教师包括在COD研究，医学博士和博士研究人员与培训科学家的强大历史卓越的领导者，并支持教师团队致力于在COD建立一个结构化的培训计划。研究团队包括神经科学家，行为健康技术专家，临床试验和应急管理专家，人类学家，统计学家，经济学家和家庭治疗师。目前，该学院有27个NIH资助的项目（NIDA [12]，NIAAA [4]，NIMH [8]，NCI [2]; NICHD [1]），以及多个基金会，教育部和VA支持的研究。在过去的10年里，由核心教师指导的博士前和博士后学生共同撰写了150多篇与他们的培训活动有关的出版物，其中约50%是第一作者。该项目将在最初的资助期内培养5-7名博士前和9-11名博士后学生。教师和参与研究计划的恒星声誉，与严格的培训生选择标准和吸引不同培训生的坚定承诺相一致，将确保科学家的发展，更好地了解科学必须解决的问题的范围，以有效地影响成瘾和精神疾病。这一群体将更具备广泛的专业知识领域，并致力于对他们感兴趣的问题采取多学科方法。

DESCRIPTION (provided by applicant): This proposal will establish a unique training program in a developing area of transdisciplinary research, co-occurring substance use and other mental disorders (COD). The need for this scientific focus is vital given that COD is more the norm than the exception among those with addictive disorders. The philosophy of this program asserts that to effectively impact the problems of addiction and mental illness, one must be fully aware of their co-existence, etiologies, phenomenology, and clinical manifestations. Moreover, knowledge of clinical approaches and the healthcare systems that serve those with addiction and mental illness is necessary to inform the questions to be asked in laboratory and clinical research studies. Embracing COD as a primary perspective is not a widely accepted approach for the training of scientists. Of NIDA's approximate sixty T32 programs, none include the words co-morbidity, dual diagnosis, or other indicators of a focus on COD. Establishing programs that prioritize training in this area will lead to the development of advanced methods for finding innovative strategies for serving those with COD. We propose to develop such a program by utilizing the unique resources and opportunities available at Dartmouth. Six interconnected groups will provide research opportunities in social, behavioral, and neurobiological mechanisms, treatment development (psychosocial and pharmacological), technology-assisted treatment and dissemination, and health services practices and implementation. Faculty include preeminent leaders in COD research, MD and PhD investigators with strong histories of training scientists, and a team of support faculty committed to establishing a structured training program in COD. Research teams include neuroscientists, behavioral health technologists, clinical trials and contingency management experts, anthropologists, statisticians, economists, and family therapists. Currently the faculty has 27 NIH-funded projects (NIDA [12], NIAAA [4], NIMH [8], NCI [2]; NICHD [1]), and multiple foundation, Department of Education, and VA supported studies. Predoctoral and postdoctoral students mentored by core faculty in the past 10 years have co-authored over 150 publications related to their training activities and were first author on approximately 50% of those. This program will train 5-7 predoctoral and 9-11 postdoctoral students in the initial funding period. The stellar reputation of the faculty and participating research programs, in concert with rigorous criteria for trainee selection and a strong commitment to attracting diverse trainees, will ensure the development of scientists with greater knowledge about the scope of issues that science must address to effectively impact addiction and mental illness. This cohort will be more equipped with broad areas of expertise and a commitment to multidisciplinary approaches to their questions of interest.