Novel Combinations of Radiation and Immunotherapy

转移性或不可切除性疾病是90%的癌症死亡的直接或间接原因，治疗转移性癌症的有效疗法很少。我的最终目标是开发方法，使我们能够在局部放疗后实现全身肿瘤控制，当需要局部放疗时。目前还没有广泛有效的全身治疗转移性软组织肉瘤的方法，但局部姑息性放射治疗是常用的，如果在姑息性放射治疗时使用免疫疗法诱导抗肿瘤免疫反应，则提供了治疗机会。放射联合免疫治疗是治疗转移性恶性肿瘤的一种很有前途的方法，我们假设放射（RT）对肿瘤微环境中免疫细胞的影响将决定不同免疫治疗（IT）方法在RT + IT联合治疗中的效用。我们正在寻找与放疗有效结合的免疫疗法，以促进全身免疫介导的转移性疾病的消退。

Metastatic or unresectable disease is the direct or indirect cause of 90% of all cancer deaths, and curative therapies for the treatment of metastatic cancers are rare. My ultimate goal is to develop methods that that enable us to achieve systemic tumor control after localized irradiation, when localized radiation therapy is indicated. There are no broadly effective systemic therapies for the treatment of metastatic soft tissue sarcomas, but localized palliative radiation therapy is commonly used and provides a therapeutic opportunity if an anti-tumor immune response is induced by immunotherapies administered at the time of the palliative radiation. Combining radiation with immunotherapy is a promising method for treating metastatic malignancies, and we hypothesized that the effects of radiation (RT) on immune cells in the tumor microenvironment will determine the utility of different immunotherapeutic (IT) methods in RT + IT combination therapies. We are identifying immunotherapies that combine effectively with radiation to promote systemic immune-mediated regression of metastatic disease.