PROTEIN SCIENCE TRANSLATION CORE

蛋白质科学翻译核心的创建是为了协助脂质组学和病理生物学科布雷的研究人员研究涉及脂类代谢和信号调节的蛋白质的结构和功能。多年来，核心已经从一个严格的咨询角色转变为在蛋白质科学的各个方面为研究人员提供服务的更积极的角色。此外，随着COBRE的大部分研究继续向临床前和翻译科学发展，核心已经成为支持这一努力的关键，使目标验证和酶定向翻译研究和疗法的研究成为可能。自2002年以来，Core已经为超过25名研究人员提供了服务，并致力于35种蛋白质的研究。在Cobre Funding的第三阶段，CORE的目标是：1)为个别研究人员生产感兴趣的蛋白质，这些蛋白质是MUSC结构和功能表征以及翻译研究计划所需的；2)提供各种与蛋白质相关的专业服务，以满足研究人员的需求，并使中心研究人员的需求与MUSC的其他现有设施相协调；以及3)通过指导、咨询和促进研讨会，加强蛋白质科学研究人员对蛋白质科学的理解和能力。总而言之，这些目标将有助于南卡罗来纳州研究人员的科学成就，他们的研究涉及蛋白质科学的某些方面，从长远来看，这可能有助于开发治疗特定疾病的药物。核心的实用性和受欢迎程度反过来将增强其在实现自我可持续性方面的前景。

The Protein Science Translation Core was created to assist Investigators of the COBRE in Lipidomics and Pathobiology in studying structures and functions of proteins involved in the regulation of lipid metabolism and signaling. Over the years, the Core has transitioned from a strictly consultative role to a more active role in servicing investigators in various aspects of protein science. Moreover, as the bulk of research in the COBRE continues to evolve towards pre-clinical and translational sciences, the Core has become essential in supporting this effort by enabling studies on target validation and enzyme-targeted translational research and therapeutics. Since 2002, the Core has serviced more than 25 investigators and worked on 35 proteins. The aims of the Core during Phase III of COBRE funding are to: 1) produce proteins of interest for individual investigators that are needed for structural and functional characterization and for translational research programs at MUSC; 2) offer a wide range of protein-related specialty services to suit the needs of investigators and to coordinate the needs of Center investigators with other existing facilities at MUSC; and 3) enhance the understanding and capability of investigators in protein science through mentoring, consultation, and promotional seminars. Taken together, these aims will contribute to the scientific achievement of investigators in South Carolina whose research involve some aspects of protein science, which in the long run could contribute to the development of drugs against specific diseases. The usefulness and popularity of the Core will in turn enhance its prospect in achieving self-sustainability.