IGF::OT::IGF MATERNAL FOLIC ACID SUPPLEMENTATION AND LEUKEMIA RISK IN CHILDREN: A POOLING OF PROSPECTIVE DATA IN THE INTERNATIONAL CHILDHOOD CANCER COHORT CONSORTIUM (I4C)

人们对儿童癌症的环境原因有着浓厚的兴趣，但很难进行研究，因为儿童患癌症的情况很少，而且很难确定过去的暴露水平，特别是在怀孕等重要时期。现在有一个独特的机会来前瞻性地研究母亲补充叶酸是否会影响儿童白血病的风险。该数据分析项目利用了国际儿童癌症队列联盟（I4C）的资源，这是一个由几个前瞻性母婴队列组成的大型联盟。为了进行这项分析，计划将I4C内五个大型前瞻性队列的数据汇集在一起。这五个前瞻性队列的总样本量为475,353名活产婴儿，来自502,466名母亲。截至2011年9月，已经发现了大约200例儿童白血病和550例各种癌症。有关于母体叶酸补充的数据以及评估混杂的数据。该分析的目的是验证孕妇补充叶酸可以降低其孩子患白血病（急性淋巴细胞白血病和其他亚型）风险的假设。

There has been a deep interest in the environmental causes of childhood cancer but it is difficult to study because cancer in children is rare and because it is difficult to identify past exposure levels, particularly during important periods such as pregnancy. There is now a unique opportunity to prospectively study whether maternal folic acid supplementation affects leukemia risk in children. This data analysis project leverages on the resource of the International Childhood Cancer Cohort Consortium (I4C), a large consortium of several prospective mother-child cohorts. For this analysis, the plan is to pool data from five large prospective cohorts within the I4C. These five prospective cohorts have a combined sample size of 475,353 live births from 502,466 mothers. Approximately 200 cases of childhood leukemia and 550 cases of all cancers combined have been identified as of September 2011. Data is available on maternal folic acid supplementation as well as data to assess confounding. The goal of the proposed analysis is to test the hypothesis that folic acid supplementation in pregnant mothers reduces the risk of leukemia (acute lymphoblastic leukemia and other subtypes) in their children.