Age Related Survival and Spontaneous Disease Phenotype in Selected Genetically Di

这两份合同的目标都是为国家毒理学计划(NTP)的危险识别活动提供支持，旨在预防因环境暴露于化学或物理制剂而导致的疾病或不良影响。毒性测试是公共卫生研究的一个重要方面，因为它用于识别对人类健康有害的化学品。在毒性研究中，必须进行适当的化学分析，以确保试验物种暴露在指定剂量浓度的指定化学品中。这些合同有助于毒性研究提供癌症风险增加的证据以及其他毒理学结果，方法是提供所研究化学物质的特性、所用剂量水平的确认以及内部剂量测定。这些信息对于评估毒性测试和制定关于研究化学品在测试物种中的潜在毒性的合理、科学的结论至关重要，并最终支持国家毒理学计划和其他联邦机构的风险评估工作。根据这份合同提供的内部剂量信息，可以对人类进行推断，以便公众能够充分了解接触所研究的化学品所产生的风险因素。 这两份合同都用于确定国家毒理学计划(NTP)选定测试试剂的毒理学潜力。 本合同用于确定国家毒理学计划(NTP)选定测试试剂的毒理学潜力。可以使用这些合同进行以下任何研究的组合。它们是：急性研究、慢性前期和慢性研究(14天、28天和90天，以及对不同品系的大鼠和小鼠的两年研究)，孕期和出生后暴露的围产期研究，通过植入式遥测评估QT延长的研究。这些研究中评估的一些终点的例子有：组织病理学、使用微阵列的差异基因表达、插入突变、临床化学、血液学、定量聚合酶链式反应等。给药途径有口服(灌胃、定量水和定量饲料)、静脉注射和IP注射，以及颌下插管。

The goal of both of these contracts are to provide support of National Toxicology Program (NTP) hazard identification activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents. Toxicity testing is an important aspect of public health research in that it serves to identify chemicals that are hazardous to human health. Proper chemical analyses are required to ensure that, in toxicity studies, the test species are exposed to the prescribed chemicals at the specified dose concentrations. These contracts contribute to the ability of toxicity studies to provide evidence of heightened cancer risk along with other toxicological outcomes, by providing characterization of the chemicals studied, confirmation of the dose levels administered, and internal dose determinations. This information is critical to evaluation of toxicity tests and development of sound, scientific conclusions about the potential toxicity of the study chemical in the test species and ultimately supports the risk assessment efforts of National Toxicology Program and other federal agencies. With internal dose information provided by this contract, extrapolations to humans can be made so that the public can be adequately informed about risk factors arising from exposure to studied chemicals. Both of these contracts are used for determining the toxicological potential of selected test agents for the National Toxicology Program (NTP). This contract is used for determining the toxicological potential of selected test agents for the National Toxicology Program (NTP). A combination of any of the following studies may be conducted using these contracts. They are: Acute studies, Prechronic and chronic studies (14-day, 28-day, and 90-day, and two year studies in various strains of rats and mice), Perinatal studies with gestational and postnatal exposure, studies to evaluate QT Prolongation via implantable telemetry. Some of the examples of the endpoints evaluated in these studies are: Histopathology, Differential Gene Expression using Microarray, Insertional mutagenesis, Clinical Chemistry, Hematology, QPCR etc. The routes of administration are oral (gavage, dosed water and dosed feed), IV and IP injections, and submandibular cannulation.