Yoga Intervention for Substance Use and ART Adherence in Community Reentry

描述(由申请人提供)：携带艾滋病毒和物质使用障碍(SUD)出狱的人具有复发14、6、50和抗逆转录病毒疗法(ART)药物依从性差的双重风险。4这些风险因与社区从监狱重新进入有关的压力而加剧。6、67拟议的研究培训补助金的目标是测试哈他瑜伽 干预措施(HYI)对最近出狱的72名艾滋病毒携带者和SUD患者的健康结局的影响。参与者将被随机分为两组，一组是由病例管理服务组成的照常治疗(TAU)，另一组是除病例管理服务外，还包括每周12节、90分钟的哈他瑜伽课的HYI。拟议的混合方法研究将考察1)与TAU相比，HYI对压力、药物使用、ART依从性、病毒载量和应对自我效能的影响；2)参与者对他们的应激反应的看法，以及这些应激反应如何受到HYI或TAU治疗的影响，通过30个半结构定性访谈进行评估。研究结果将有助于为艾滋病毒携带者和从监狱重新进入社区的SUD患者制定干预措施。 拟议的随机对照试验将通过宾夕法尼亚大学的课堂作业和研究研讨会提供广泛的定量和定性培训，以及赞助商Jim McKay博士和共同赞助商Malitta Engstrom博士的指导来完成。

DESCRIPTION (provided by applicant): People who leave prison with HIV and a substance use disorder (SUD) have the dual risks of relapse 14,6,50 and poor antiretroviral therapy (ART) medication adherence.4 These risks are exacerbated by the stress associated with community re-entry from prison.6, 67 The goal of the proposed research training grant is to test a hatha yoga intervention's (HYI) impact on the health outcomes of 72 people recently released from prison with HIV and SUD. Participants will be randomized to either treatment as usual (TAU) comprised of case management services, or HYI comprised of 12-weekly 90-minute hatha yoga classes in addition to case management services. The proposed mixed methods study will examine 1) the effects of HYI on stress, substance use, ART adherence, viral load and coping self-efficacy as compared with TAU; and 2) participants' perspectives regarding their stress responses and how these stress responses are affected by treatment assignment to HYI or TAU, as assessed through 30 semi-structured qualitative interviews. Findings will inform the development of interventions for people with HIV and SUD experiencing re-entry to the community from prison. The proposed randomized controlled trial will be accomplished through extensive quantitative and qualitative training provided by classwork and research seminars at the University of Pennsylvania, and mentorship from sponsor Dr. Jim McKay and co-sponsor Dr. Malitta Engstrom.