User Interface Portal

西奈山KMC-IDG的用户界面门户(UIP)将开发一个最先进的网站，用于托管演示和访问DOC收集的数据。该网站将为每个正在研究中的可用药靶点提供一个专门的页面，使用不同的插件工具来探索每个靶点的各个方面，包括：蛋白质结构、蛋白质-蛋白质相互作用、转录因子的调节、小鼠表型、不同组织和条件下的表达谱、小鼠敲除表型、基因本体论信息、翻译后修饰等等。此外，该门户将实现各种应用的交互式可视化，这些应用将把正在研究的目标放在由患者、细胞系、疾病/副作用/表型、药物和其他基因和蛋白质组成的网络中。UIP将拥有一个强大的搜索引擎，可以为DOC中的所有实体编制索引，并将学习用户体验。UIP将使用户能够根据用户的具体需求建立自己的数据分析管道。此外，统一信息平台将采用插件式架构设计，使社区能够贡献数据分析和可视化工具。

The User Interface Portal (UIP) of the Mount Sinai's KMC-IDG will develop a state-of-the-art web-site that would host the presentation and access to the data collected by the DOC. The web-site will have a dedicated page of each under-studied druggable target with different plug-in tools to explore the various aspects of each target including: protein structure, protein-protein interactions, regulation by transcription factors, mouse phenotypes, expression profiles in different tissues and conditions, mouse knockout phenotypes, gene ontology information, post-translational modification and many more. In addition, the portal will enable interactive visualization of various applications that will place the under-studied targets within networks made of cohorts of patients, cell lines, diseases/side-effects/phenotypes, drugs and other genes and proteins. The UIP will have a powerful search engine that would index all entities in the DOC and will learn from user experience. The UIP will enable users to build their own data analysis pipelines based on the user specific needs. In addition, the UIP will be designed in a plug-in architecture to enable the community to contribute data analysis and visualization tools.