(PQD2) Why is Endemic Burkitt Lymphoma Curable with Single Agent Chemotherapy?

描述（由申请人提供）：此申请是对RFA-CA12-022的响应。它解决了PQD - 2什么分子特性使得一些癌症可以用常规化疗治愈？我们选择EBV+地方性伯基特淋巴瘤（BL）作为典型的癌症，可以用单药（环磷酰胺）治愈bbb90 %的儿童。这种极高的治愈率在20世纪60年代在非常有限的环境中（乌干达）已经很明显，此后在美国、巴西和其他国家也重复出现。失败是由于包括社会经济和总体表现评分在内的共同因素，这些因素限制了患者完成规定的周期数量，而不是分子异质性。因此，这种极具侵袭性的癌症可以治愈的原因是分子性质的。我们将使用功能遗传学方法来了解使BL对最简单的化疗之一敏感的分子特性。

DESCRIPTION (provided by applicant): This application is in response to RFA-CA12-022. It addresses PQD - 2 what molecular properties make some cancers curable with conventional chemotherapy? We choose EBV+ endemic Burkitt lymphoma (BL) as the prototypical cancer that is curable with single agent (cyclophosphamide) in >90% of children. This exceedingly high cure rate was already evident in the 1960s in very limited settings (Uganda) and has since been repeated in the US, in Brazil and other nations. Failure is due to co-factors, including socioeconomically and over all performance score, which limit the patients to complete the prescribed number of cycles, rather than molecular heterogeneity. Hence, the reason that this very aggressive cancer is curable is molecular in nature. We will use a functional genetic approach to understand the molecular properties that render BL susceptible to one of the simplest of chemotherapies.