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Regulation of rodent energy metabolism, body weight and composition

Regulation of rodent energy metabolism, body weight and composition
啮齿动物能量代谢、体重和成分的调节
批准号：
8939492
负责人：
KEVIN HALL
金额：
$6.82万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8939492
关键词：
BehaviorBody CompositionBody WeightBody Weight decreasedBrainCorpus striatum structureDataDevelopmentDiabetes MellitusDietDopamineEatingEnergy MetabolismFood EnergyInvestigationMolecularMusObesityOrganismPhysical activityRegulationRodentRoleSignal TransductionWeight Gainenergy balanceimprovedinterestmathematical modelmouse model

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中文摘要
翻译
我们建立了一个小鼠能量代谢的数学模型，为研究肥胖和糖尿病小鼠模型中的能量平衡关系提供了一个定量框架。我们现在正在研究小鼠的体重调节受到各种随意饮食诱导体重增加和减少。我们对纹状体多巴胺信号在食物摄入和身体活动行为中的作用特别感兴趣，我们正在研究不同饮食的体重增加和减少如何导致大脑多巴胺信号的变化。
英文摘要
We created a mathematical model of mouse energy metabolism that provides a quantitative framework for investigating energy balance relationships in mouse models of obesity and diabetes. We are now investigating body weight regulation of mice subjected to various ad libitum diets inducing weight gain and loss. We are particularly interested in the role of striatal dopamine signaling in food intake and physical activity behavior and we are studying how weight gain and loss on various diets leads to changes in brain dopamine signaling.
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会议论文
Interactions of diet, exercise, metabolism, and weight change in humans
Regulation of rodent energy metabolism, body weight and composition
Computational modeling of human metabolism, body weight and composition
Metabolic and body composition changes during rapid and massive weight loss
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