Translational Drug Abuse Prevention Center

描述（由申请人提供）：拟议的P50中心，转化药物滥用预防（TDAP）的目的是作为一个国家资源，为药物滥用的前沿，多学科，科学创新和协同的I型和II型转化预防研究奠定基础，为儿童福利系统（CWS）的未来研究，实践和政策奠定基础。参与劳教的儿童和青少年，以及在劳教后被收养的儿童和青少年，吸毒、艾滋病毒风险以及相关问题（包括犯罪和精神健康状况不佳）的风险大大增加。TDAP中心将扩展我们之前在药物滥用预防方面的工作，并通过一个涵盖I型和II型预防研究的综合研究项目，扩大我们在这一领域的基础和干预工作的范围和影响，这将增加我们对三个对CWS政策和实践有直接影响的关键领域的理解：(1)了解与暴露于高水平的早期生活逆境相关的潜在机制和过程，以及特定社会环境中风险决策的过程，这是CWS青少年在青春期早期常见的；(2)通过新颖的预防干预策略降低贫困地区少女吸毒和参与艾滋病毒风险行为的高发率；(3)在公共儿童福利系统发起的改革背景下，确定在CWS现实环境中实施现有循证干预措施的方法，并对实施的成功/失败进行实证衡量。以上的研究组成部分将由一个方法和统计核心提供支援，以便对传入的数据进行综合定性和定量分析，并将新数据与我们现有的大量水气研究数据资源相结合。试点和培训核心将支持小规模研究的发展，这些研究旨在导致由早期职业和少数民族研究人员在预防药物滥用和艾滋病毒风险领域领导的创新、新的独立研究项目。最后，行政核心将在中心内提供领导，与由CWS领导人和政策制定者专家组成的外部咨询委员会对接，并促进对早期职业科学家的培训和指导。

DESCRIPTION (provided by applicant): The purpose of the proposed P50 Center, Translational Drug Abuse Prevention (TDAP), is to serve as a national resource for cutting-edge, multidisciplinary, scientifically innovative and synergistic Type I and II translational prevention research in drug abuse that seeds future research, practice, and policy in the child welfare system (CWS). Children and adolescents with involvement in the CWS, and those adopted following CWS involvement, are at greatly elevated risk for drug use, HIV-risk, and associated problems including delinquency and poor mental health. The TDAP Center will extend our previous work on drug abuse prevention and broaden the reach and impact of our basic and intervention work in this area through an integrated program of research spanning Type I and Type II prevention research that will increase our understanding in three key areas that have direct effects on CWS policy and practice: (1) Understanding of underlying mechanisms and processes associated with exposure to high levels of early life adversity, and specific to risky decision-making in certain social contexts that are common for CWS youth during early adolescence; (2) reducing the high rates of drug use and engagement in HIV-risk behaviors in adolescent girls in the CWS via novel preventive intervention strategies; and (3) identifying methods for implementing extant evidence-based interventions into CWS real-world settings with high fidelity and empirically measuring implementation success/failure in the context of a public child welfare system-initiated reform. The above Research Components will be supported by a Methodology and Statistics Core that will facilitate integrated qualitative and quantitative analyses of the incoming data, as well as integrate the new data with our large existing data resource of CWS studies. A Pilot and Training Core will support the development of small-scale studies designed to lead to innovative, new independent research projects led by early career, and minority researchers in the area of prevention of drug abuse and HIV-risk in the CWS. Finally, an Administrative Core will provide leadership within the Center, interface with an external Advisory Board comprised of experts in CWS leaders and policy makers, and facilitate training and mentoring of Early Career Scientists.