Administrative Core

项目摘要(见说明)：管理核心为三个项目和本方案项目的另外两个核心提供管理服务。该计划项目提案汇集了几个小组的独特人才，对p66Shc缺乏延长寿命的机制进行了综合和跨学科的分析，跨越了生物组织的几个水平，并利用了许多不同类型的分析，生成了多种格式的数据。行政核心是项目和核心之间协同互动的核心，事实上，自提案最初提交以来，行政核心已经证明了这些小组之间研究交易的便利化。作为这种协同作用的结果，该计划为SHE功能产生了多个新的假设。通过过去4.5年的协调，该计划项目进行的研究已经证明，SHCS控制肥胖、新陈代谢、胰岛素信号和应激抵抗，管理核心促进了我们实验室&gt；手稿的出版。这一核心的具体目标是：1)提供一个组织结构，以加快和协调研究，促进研究人员之间的互动；2)监测和定期审查研究的质量，并准备进度报告；3)管理计划项目的财政部分；4)促进出版、演示和研究成果的传播；5)组织项目成员和外部审查委员会的年度会议；以及6)协调和监测数据和资源共享。作为如何实现这些目标的核心，核心A将组织和管理每月一次的电话会议、每周一次的实验室会议、外部咨询委员会年度会议以及七个单位之间数据交换的网络服务器。

PROJECT SUMMARY (See instructions): The Administrative Core provides administrative services to the three projects and two other cores of this program project. The program project proposal brings together the unique talents of several groups to perform an integrative and interdisciplinary analysis of the mechanism by which p66Shc-deficiency extends lifespan, across several levels of biological organization, and utilizing analyses of many different types that generate data in multiple formats. The Administrative Core is central to the synergistic interaction of the projects and cores, and in fact has demonstrated the facilitation of research transactions between these groups since the proposal's original submission. As a result of this synergistic interaction, the program has generated multiple new hypotheses for She function. Through this coordination over the last 4.5 years, the research conducted by the program project has demonstrated that Shcs control adiposity, metabolism, insulin signaling, and stress resistance, and the Administrative Core has facilitated the publication of >64 manuscripts from our laboratories. The Specific Aims of this core are: to 1) provide an organizational structure to expedite and coordinate research and promote interactions among investigators; 2) monitor and regularly review the quality of research and prepare progress reports; 3) manage the fiscal components of the program project; 4) facilitate publications, presentations, and the dissemination of research results; 5) organize annual meetings by project members and an external review committee; and 6) coordinate and monitor data and resource sharing. Central to how these Aims will be achieved, Core A will organize and manage the monthly teleconference, the weekly lab meetings, the annual External Advisory Committee meeting, and the web-based server for data interchange between the seven units.