DATA MANAGEMENT AND STATISTICS

加州大学洛杉矶分校ADRC数据管理和统计核心(DMSc)开发了复杂的最先进的数据管理基础设施，用于中心范围的数据处理、信息存储、数据检索和无错误数据共享。DMSc拥有与国家阿尔茨海默病协调中心(NACC)完全兼容的数据结构，并在上一个赠款周期的审计中满足了所有数据管理标准。错误检查程序已到位，以确保持续的数据质量。具备编程技能的工作人员可对统一数据集(UDS)和其他数据导出的演变作出反应 要求。DMSc数据库包括所有临床、遗传、生物标记物和NACC授权的神经病理学数据，以及可用成像清单。DMSc成员参与临床核心的评分员培训活动，以确保高质量的数据捕获。除专家数据管理外，DMSc还提供与ADRC支持的核心和项目相关的方法、研究设计和数据分析问题的咨询。核心领导者David Elashoff博士在分析大型蛋白质组和基因组数据集方面拥有专业技能--智力资本与ADRC的治疗必要性主题以及生物标记物在ADRC活动中日益重要的重要性具有重要的协同作用。DMSc成员参与试点项目计划的研究审查委员会，并就所有提交给该计划的报告提供方法和设计反馈。DMSc有一个积极的计划，在统计方法和负责任的研究行为方面指导初级教职员工和受训人员。DMSc教职员工参与执行委员会和临床研究委员会，并 与招聘和教育核心部门合作，维护和更新ADRC网站。DMSc代表了加州大学洛杉矶分校ADRC的基本信息架构。

The UCLA ADRC Data Management and Statistics Core (DMSC) has developed a sophisticated state-of-the-art data management infrastructure for center-wide data processing, information storage, data retrieval, and errorless data sharing. The DMSC has a data structure completely compatible with the National Alzheimer Coordinating Center (NACC) and has met all standards of data management in audits of the last grant cycle. Error checking programs are in place to insure continuing data quality. Staff members with programming skills are available to respond to the evolution of the uniform data set (UDS) and other data export requirements. The DMSC database includes all clinical, genetic, biomarker, and NACC-mandated neuropathology data as well as an inventory of available imaging. DMSC members participate in rater-training activities of Clinical Core to insure quality data capture. In addition to expert data management, the DMSC provides consultation on methodologic, research design, and data analysis issues related to the Cores and Projects supported by the ADRC. The Core Leader, David Elashoff, PhD, has specialized skills in analysis of large proteomic and genomic data sets - intellectual capital that has an important synergy with the ADRC's theme of the therapeutic imperative and the increasing importance of biomarkers in ADRC activities. Members of the DMSC participate in the Research Review Committee of the Pilot Project program and provide methodologic and design feedback on all submissions to the program. The DMSC has an active program for mentoring of junior faculty and trainees in statistical methods and responsible conduct of research. DMSC faculty participate in the Executive Committee and Clinical Research Committee and collaborates with the Recruitment and Education Core in maintaining and updating the ADRC website. The DMSC represents the essential informatic architecture of the UCLA ADRC.