West Coast Salt and Water Club Annual Meeting

描述(申请人提供)：水和电解质的动态平衡是人体生理学和病理生理学的一个重要方面。参与这种动态平衡的主要器官包括但不限于肠道和肾脏，其中的紊乱可以影响几乎每个器官系统。在这一概念的基础上，西海岸盐水俱乐部(WCSWC)成立于20世纪60年代初，最初是一个运输生理学俱乐部，后来扩展到包括各种系统中的离子和溶质运输、上皮细胞生物学和细胞调控机制。本申请申请为将于3月8日至9日在加利福尼亚州莫罗湾举行的2013年WCSWC第二次会议提供资金。这次会议代表了一系列独特的跨学科年度会议中的32次，会议的重点是上皮运输和细胞间/细胞内通信机制的作用。自发起以来，这一年度会议一直引以为豪的是，它将该领域的初级研究人员和知名领导人聚集在一起，介绍他们最新的未发表的发现，并参与有意义的科学和社会互动。WCSWC的非正式性质在促进跨越多个学科的讨论方面是独一无二的，并使新的个人和科学联系得以发展。因此，每年都有非常多的科学家回到这个会议上。参与者是基础科学家和临床医生的很好组合，他们在正常和疾病的调节方面有着共同的兴趣。2013年的主旨演讲者将讨论与NIDDK相关的两个重要主题：(I)近端小管在糖尿病肾脏中的作用；(Ii)腺苷在镰状细胞疾病中的作用。这次会议的目的是：(A)提供一个论坛，允许研究人员介绍各种系统中的离子和溶质运输、上皮细胞生物学和细胞内调控机制等一系列主题的工作；(B)营造包容、紧张、活跃和互动的氛围，突出该领域的最新研究，并通过提供对悬而未决的问题的更深层次的理解来启发与会者；(C)将来自几个学科的科学家聚集在一起，这些科学家将从串扰中受益，但通常不会相互或持续地相互作用；以及(D)为促进富有成效的合作和吸引青年研究人员(研究生、博士后和初级教员)，特别是妇女、少数群体和残疾人到实地工作提供持续论坛。会议期间的所有陈述都是令人兴奋的、及时的，旨在将新的发现转化为对疾病机制、诊断、预防和治疗的更好理解。以前的与会者经常期待这次会议，新的与会者和青年科学家认为这是一次宝贵的学习和职业经历。

DESCRIPTION (provided by applicant): Water and electrolyte homeostasis is a crucial aspect of human physiology and pathophysiology. Major organs involved in this homeostasis include, but are not limited to, the intestine and kidneys, and disturbances therein can affect almost every organ system. With the basis of this concept, the West Coast Salt and Water Club (WCSWC) was initiated in the early 1960s as a transport physiology club and has since expanded to include ion and solute transport, epithelial cell biology, and cellular regulatory mechanisms in a variety of systems. This application requests funds for the 2013 WCSWC nd meeting to be held in Morro Bay, California, March 8-9. This meeting represents the 32 in a unique series of annual interdisciplinary meetings focused on the role of epithelial transport and inter-/intra-cellular communication mechanisms. Since its initiation, this annual meeting has prided itself on bringing together junior investigators and established leaders in the field to present their latest unpublished findings and engage in meaningful scientific and social interactions. The informal nature of the WCSWC is unique in fostering discussions that span multiple disciplines and enables new personal and scientific connections to develop. As a consequence, an extraordinarily high number of scientists return to this conference annually. The participants are a good mix of basic scientists and clinicians who share common interests in the regulation of normal and diseased. The 2013 keynote speakers will cover two important topics relevant to the NIDDK: (i) the role of the proximal tubule for the diabetic kidney and (ii) he role of adenosine in sickle cell disease. The objectives of this conference are to: (a) provide a forum that allows investigators to present work on a range of subjects, including ion and solute transport, epithelial cell biology, and intracellular regulatory mechanisms in a variety of systems (b) foster an inclusive, intense, lively and interactive atmosphere that highlights the latest research in the field and enlightens participants by providing a deeper understanding of unresolved issues; (c) bring together scientists from several disciplines that would benefit from crosstalk but do not typically or consistently interact with each other; and (d) provide a continuing forum for fostering productive collaborations and attracting young investigators (graduate students, postdocs and junior faculty), particularly women, minorities and disabled individuals, to the field. All presentations during the meeting are exciting, timely and aim to translate new findings into a better understanding of disease mechanisms, diagnosis, prevention and treatment. Previous participants regularly look forward to this meeting, and new attendees and young scientists recognize it as an invaluable learning and career experience.