Investigating a tumour suppressor in haematopoiesis and lymphoblastic leukaemia

急性淋巴细胞性白血病是最常见的儿童癌症。不幸的是，目前对癌症儿童的治疗往往会导致严重的与治疗相关的疾病，这强调了对新疗法的需要。在拟议的项目中，我们将研究急性淋巴细胞性白血病中常见突变基因的分子和细胞功能，目的是确定潜在的分子机制，这些机制可能允许未来开发新的治疗方案。

Acute lymphoblastic leukaemia is the most common childhood cancer. Current treatment of children with cancer unfortunately often results in severe treatment-related disease, emphasising the need for novel therapies. In the proposed project, we will examine the molecular and cellular functions of a gene commonly mutated in acute lymphoblastic leukaemia with the aim of identifying underlying molecular mechanisms that may allow the development of new therapeutic options in the future.