Identification of Early Psoriatic Arthritis

描述（由申请人提供）：银屑病关节炎（Psoriatic arthritis, PsA）是一种与银屑病相关的慢性、衰弱性炎症性关节炎。迄今为止，大多数研究只包括患有长期疾病的患者。我们知道，从类风湿关节炎，另一种类型的炎症性关节炎，早期识别和治疗开始提高对治疗的反应，减少关节损伤和残疾。这可能也是PsA的情况，但到目前为止，PsA很难在疾病过程的早期识别。此外，对PsA的早期阶段所知甚少。由于大多数PsA患者首先发展为牛皮癣，因此患者

DESCRIPTION (provided by applicant): Psoriatic arthritis (PsA) is a chronic, debilitating inflammatory arthritis associated with psoriasis. Most studies to date include only patients with long standing disease. We know from rheumatoid arthritis, another type of inflammatory arthritis, that early identification and treatment initiation improves response to therapy and decreases joint damage and disability. It is possible that this is also the case in PsA, but to date, PsA is very difficult to identify early in the course of disease. Furthermore, very little is known about he earliest phases of PsA. As the majority of patients with PsA first develop psoriasis, patients with psoriasis represent an ideal population for studies investigating the development of PsA. In this application, we propose two approaches to detecting early disease: 1) to identify risk factors for development of PsA among patients with psoriasis, and 2) to identify subclinical articular and periarticular inflammation in patients with psoriasis, possibly the earliest form of the disease, using 18F-Flurorodeoxyglucose Positron Emission Tomography/Computed Tomography and musculoskeletal ultrasound. Not only will these studies address two potential approaches for identifying early disease, but through these innovative investigations we will gain insight into th natural history and pathophysiology of PsA development. The candidate is a rheumatologist and clinical investigator with an interest in inflammatory arthritis, particularly psoriatic arthriis, with a scientific background ideally suited for the K23 mentored career development award. Her goal is to become a successful, independently funded clinical investigator. Through the outlined career development plan and the proposed research, Dr. Ogdie will gain the required skills to achieve independence and to address her long-term objectives. The University of Pennsylvania is the ideal environment in which to conduct the proposed studies. Dr. Ogdie will leverage two existing R01 funded studies directed by the co-mentor to address the research Aims. With tremendous resources in rheumatology, dermatology, epidemiology, and radiology as well as outstanding mentorship, facilities, and equipment, Dr. Ogdie will build a strong foundation for career in patient-oriented clinical and translational investigation.