Investigating underlying mechanisms linking Type 2 diabetes with Alzheimer’s disease pathology

由于2型糖尿病是阿尔茨海默病等神经退行性疾病的主要风险因素，了解其潜在的机制是很重要的。这个项目将提供对T2D如何影响大脑的重要洞察，重点是大脑输入信号的缺陷如何驱动神经退化。我们还将评估新的inuslin样分子在改善大脑胰岛素信号和防止或减缓神经退变过程方面的作用。

With type-2 diabetes representing a major risk factor for neurodegenerative diseases such as Alzheimer's disease, it is important to understand the underlying mechanisms. This project will provide significant insight into how T2D impacts the brain with a focus on how deficiencies in brain inuslin signaling drives neurodegeneration. We will also evaluate novel inuslin like molecules at improving brain insulin siganling and preventing or slowing down the neurodegenerative process.