IGF::OT::IGF Coronary Artery Risk Development in Young Adults (CARDIA) Study -

青壮年冠状动脉风险发展（CARDIA）研究由国家心肺血液研究所（NHLBI）于1985年建立，旨在研究美国四个社区（阿拉巴马州伯明翰、伊利诺伊州芝加哥、明尼苏达州明尼阿波利斯和加利福尼亚州奥克兰）青壮年心血管疾病风险的分布和演变（http://www.cardia.dopm.uab.edu/）。最初的队列（n= 5115）被选择在每个社区的年龄（18-24岁和25-30岁）、性别、种族（黑人和白人）和教育（高中或高中以下和高中以上）的亚组中有大约相同数量的参与者。在第30年的第八次检查（2015年7月1日至2016年6月30日），参与者将在48-60岁之间，这是危险因素和亚临床异常普遍存在的时期，临床事件不断出现。CARDIA提供了解决老年人群无法解决的亚临床和临床疾病的发展和进展方面的机会。具体来说，CARDIA提供了早期心血管疾病表型的机会，包括大量白人和黑人成年人的心力衰竭。此外，心血管疾病的危险因素也可以更新。根据先前检查的危险因素数据，CARDIA能够研究成年早期到中年中晚期的整个轨迹，以及它们的控制如何影响心功能障碍的发生和进展。

The Coronary Artery Risk Development in Young Adults (CARDIA) study was established in 1985 by the NationalHeart, Lung, and Blood Institute (NHLBI) to study the distribution and evolution of cardiovascular disease riskbeginning in young adulthood in four U.S. communities (Birmingham, AL; Chicago, IL; Minneapolis, MN; and Oakland,CA) (http://www.cardia.dopm.uab.edu/). The original cohort (n=5,115) was selected to have approximately the samenumber of participants in subgroups of age (18-24 and 25-30), sex, race (black and white), and education (high schoolor less and more than high school) within each community. At Year 30 the eighth examination (July 1, 2015- June30, 2016), participants will be 48-60 years old, a time when risk factors and subclinical abnormalities are prevalentand clinical events continue to emerge. CARDIA offers the opportunity to address aspects of the development andprogression of subclinical and clinical disease that cannot be addressed in older cohorts. Specifically, CARDIA offersthe opportunity to phenotype early cardiovascular disease, including heart failure in a large cohort of white andblack adults. In addition, risk factors for cardiovascular disease can be updated. With risk factor data from previousexaminations, CARDIA has the ability to study how the entire trajectory of early adulthood to mid-to-late middle-agerisk factors and their control affects development and progression of cardiac dysfunction.