The Eighth International Mdm2 Workshop

 描述(由申请人提供)：项目摘要/摘要P53蛋白在人类癌症中发挥肿瘤抑制作用已被很好地描述。事实上，大多数人类肿瘤都存在TP53基因的错义突变。MDM2是P53的主要负调控因子，通过直接结合抑制P53的转录活性，并作为E3泛素连接酶作用于P53的降解。与这些发现一致的是，MDM2也被证明在人类肿瘤中发挥作用，在各种癌症中观察到它的过度表达或基因扩增。第8届国际MDM2研讨会的科学需求源于P53肿瘤抑制因子及其负调控因子MDM2在人类癌症的发生和发展中所起的核心作用，以及P53-MDM2相互作用对开发新疗法的承诺。随着研究MDM2的科学界的扩大，以及需要以多学科协作的方式开展这一领域的研究，进一步有必要举办MDM2讲习班。因此，虽然P53和MDM2讲习班最初都是实地研究人员的小型聚会，但它们已成为未来取得进展所必需的。每两年举行一次P53讲习班，将P53领域聚集在一起，以报告最新研究，并促进合作和试剂交流。第一次P53研讨会于1983年在英国举行。14年前，第一次与MDM2相辅相成的讲习班与p53会议隔年举行。自那以后，研讨会每两年举行一次，在欧洲和美国轮流举行。第八届国际MDM2研讨会将于2015年11月1日至4日在杜兰大学医学院举行。会议由华鲁(杜兰大学)和魏谷(哥伦比亚大学)联合举办。会议地点在路易斯安那州新奥尔良Poydras Street 1555号Bowers礼堂。杜兰大学是1555 Poydras大楼的主要长期承租人。这个礼堂为杜兰社区举办研究研讨会和医学生班。因此，我们正在申请R13基金，以支持这一领域最高级别和令人兴奋的国际会议，这将极大地重新激发研究的活力，促进该领域的科学互动和交流。

 DESCRIPTION (provided by applicant): Project Summary/Abstract The p53 protein has been well characterized as playing a tumor suppressor role in human cancer. Indeed, a majority of human tumors have sustained missense mutation in the TP53 gene. Mdm2 is a major negative regulator of p53 that has been shown to act by inhibiting the transcriptional activity of p53 via direct binding as well as serving as an E3 ubiquitin ligase to target p53 for degradation. Consistent with such findings, Mdm2 has been demonstrated as also playing a role in human tumors with its overexpression or gene amplification being observed in a variety of cancers. The scientific need for the 8th International MDM2 Workshop arises from the central role that the p53 tumor suppressor and its negative regulator Mdm2 have regarding the development and progression of human cancer and the promise that the p53-Mdm2 interaction holds for development of novel therapies. The expansion of the scientific community studying Mdm2 and the need to pursue this area of research with a collaborative multidisciplinary approach has further made it necessary to have Mdm2 Workshops. Thus, while both the p53 and Mdm2 Workshops started as small gatherings of researchers in the field, they have become necessary for future progress. A p53 Workshop is held every two years to bring together the p53 field in order to report on the latest research and to facilitate collaboration and exchange of reagents. The first p53 Workshop was held in 1983 in the United Kingdom. Fourteen years ago, the first complementing Mdm2 Workshop was held in alternating years with the p53 conference. The Workshops have since been held every two years, alternating between Europe and the United States. The 8th International MDM2 Workshop will be held at Tulane University School of Medicine on November 1-4th, 2015. The meeting is being co-organized by Hua Lu (Tulane University) and Wei Gu (Columbia University). The site of the conference is in the Bowers Auditorium, 1555 Poydras Street, New Orleans, Louisiana. Tulane University is a major long-term leasee of the 1555 Poydras building. This Auditorium hosts research seminars and medical student classes for the Tulane Community. Therefore, we are applying for the R13 fund to support this highest level and exciting international meeting in this field, which would dramatically re-energize the research and promote scientific interactions and exchanges in the area.