Investigation of Dok2 and Dok1 adapter proteins, in the negative regulation of integrin aIIbb3 platelet signalling.

血小板在血栓形成、预防出血方面发挥着关键作用，也是导致心脏病发作和中风的血栓形成的主要因素。许多研究已经确定了促进血小板活性的途径，但对其负调控知之甚少。在这项资助中，我们将研究蛋白质Dok2和Dok1在血小板负调控中的作用，希望这能导致预防心脏病的新疗法的发展。

Blood platelets play a key role in blood clot formation, prevention of bleeding and are the principal elements contributing to thrombosis leading to heart attack and stroke. Numerous studies have defined pathways promoting platelet activity, however less is known about their negative regulation. In this grant we will examine the role for proteins, Dok2 and Dok1, in the negative regulation of platelets, hoping this leads to development of novel therapeutics for prevention of cardiac disease.