Long-lived CD19-positive plasma cells

描述(由申请人提供)：维持血清中抗外来和自身抗原抗体所需的信号和事件仍不明确。这项应用的主要目的是评估最近形成的抗体在骨髓(BM)中分泌浆细胞在这些过程中的作用，并确定最近形成的和长期存活的浆细胞用来避免细胞死亡的细胞因子。为了实现这些目标，我们将：1)确定新形成的BM PC在长寿抗体介导的免疫中的作用；2)定义新形成的和长寿命的BM PC在抗体介导的自身免疫中的作用；以及3)确定IL-5和BAFF家族细胞因子在维持TI抗原诱导的PC中的作用。这些研究将加强对对非自身和自身抗原的长期抗体反应形成和维持的潜在过程的了解，从而为优化疫苗接种策略和抗击抗体介导的自身免疫性疾病提供战略依据。

DESCRIPTION (provided by applicant): The signals and events required for maintaining serum antibodies to foreign and self- antigens remain poorly defined. The main goals of this application are to evaluate the role of recently formed antibody secreting plasma cells in the bone marrow (BM) in these processes, and to define the cytokines that recently formed and long-lived plasma cells employ to avoid cell death. To achieve these objectives we will: 1) Define the role of newly formed BM PCs in long-lived antibody-mediated immunity; 2) Define the role of newly formed and long-lived BM PCs in antibody-mediated autoimmunity; and 3) Define the roles of IL-5 and BAFF family cytokines in the maintenance of TI antigen-induced PCs. These studies will enhance knowledge of the processes underlying formation and maintenance of long-lived antibody responses to both non-self and self-antigens, and consequently inform strategies to optimize vaccination strategies and combat antibody mediated autoimmune disease.