IGF::OT::IGF TO 5 Maintenance of the Caloric Restricted Colonies Transferred from Contract N01-AG-40003.

热量限制，即限制热量以维持稳定的成人体重，但满足所有其他营养需求，是唯一经证实的延长寿命和改善健康的干预措施。热量限制啮齿动物被用来研究正常衰老的细胞和生理生物学。一群年老的、热量限制的实验室啮齿动物，具有明确的遗传背景和健康状况，是NIA衰老研究项目的一个组成部分。这个项目的目的是发展、维持和分布一个固定的衰老、热量限制的啮齿类动物种群，供研究人员用于衰老研究。

Caloric restriction, in which the calories are restricted to maintain a stable adult body weight but all other nutritional needs are met, is the only proven intervention to extend life span and improve health. Calorically restricted rodents are used to investigate the cellular and physiological biology of normal aging. A colony of aged, calorically restricted laboratory rodents, of defined genetic backgrounds and health status, is an integral part of the NIA's program of research on aging. The purpose of this project is to develop, maintain and distribute a standing colony ofaged, calorically restricted rodents ofdefined strains for use by investigators in studies of aging.