Assessing and Understanding the Impact of Physcial and Biological Factors on

该项目的目标是评估和提高我们对以下方面的重要性和临床影响的认识： (a)关于质子物理相互作用的当前质子治疗的假设和近似 （B）质子的显著不同的剂量分布模式 和光子，以及（c）质子的相对生物有效性（RBE）的可变性的假设 与目前使用1.1的恒定RBE的做法相比。这一目标将部分实现 通过分析P01临床试验的临床数据（局部对照、毒性和影像学缓解） 部分是通过计算机模拟和体内实验。实现这一目标具有重要意义。 重要性在于获得的关于影响治疗反应的因素的知识（例如，间和 分次内解剖变异、预测物理剂量的近似值、RBE变异性等）将 对于质子治疗的适当性做出可靠的治疗决定至关重要， 评估计划质子剂量分布的临床有效性，并用于开发先进的 设计最佳和稳健的IMPT的方法，以充分利用质子治疗的潜力。这个项目 支持NCI的使命，改善癌症患者的治疗和持续护理。

The goal of this project is to assess and improve our understanding of the magnitude and clinical impact of (a) assumptions and approximations of current proton therapy regarding the physical interactions of protons with patient anatomy and treatment devices, (b) the markedly different dose distribution patterns of protons and photons, and (c) the assumption of the variability of the relative biological effectiveness (RBE) of protons compared to the current practice of using a constant RBE of 1.1. This goal will be accomplished partly through the analyses of clinical data (local control, toxicities and imaged response) from the P01 clinical trials and partly through computer simulations and through in-vivo experiments. Achieving this goal is of high significance in that the knowledge gained about the factors affecting treatment response (e.g., inter- and intra-fractional anatomic variations, approximations in predicting physical dose, RBE variability, etc.) would be critical for making reliable treatment decisions about the appropriateness of proton therapy, for correctly evaluating the clinical effectiveness of planned proton dose distributions, and for developing advanced methods to design optimum and robust IMPT to exploit the full potential of proton therapy. This project supports the mission of the NCI to improve the treatment and continuing care of cancer patients.