Computerized Quantitative Imaging Assessment of Tumor Burden

描述(申请人提供)：定量成像方法有望提高癌症研究人员评估肿瘤负担和治疗反应的能力，但由于缺乏在常规临床工作流程中高效和可重复地记录定量成像信息的软件基础设施，以及无法以标准格式存储和共享图像元数据，进展受到阻碍。许多可以更完整地描述肿瘤负担的不同定量成像特征没有被捕获，因为在没有工具支持的情况下收集这些信息是费力的。我们的目标是开发软件基础设施，通过三个目标满足癌症研究人员的这些需求：(1)创建利用caBIG技术的工具，以标准化对肿瘤负担的定量成像评估。这些工具将作为常规临床工作流程的一部分，对肿瘤负担的定量成像特征进行全面和可重复的评估，并将改善放射科医生和肿瘤学家在收集定量图像数据方面的协调。通过商业合作伙伴关系，我们将在一个商业图像解释工作站中整合我们工具的功能，以将我们的方法引入临床实践；(2)开发分析定量图像元数据的方法，并帮助肿瘤学家评估作为临床试验一部分收集的图像的量化标准；以及(3)通过在两个临床试验中应用我们的工具来评估我们基础设施的实用性，并展示我们的软件基础设施能够定量且更具重复性地测量肿瘤负担，帮助研究人员评估单个患者和患者队列的治疗反应。我们的基础设施将提供在多个维度上查看与治疗反应相关的定量成像信息的新方法，以便研究人员能够更好且可能更快地识别临床试验中治疗的有效性，而不是使用目前的无辅助方法。我们的工作将加速癌症研究中的定量成像，并将为定量成像网络中专注于个人定量成像方法的其他中心提供必要的补充。 相关性：我们开发的方法和工具将提高癌症研究人员收集和使用定量成像数据的能力，以准确评估肿瘤负担，并开发改进的方法来评估治疗是否有效。提高定量成像在评估个别患者治疗反应方面的准确性将使更好的治疗选择成为可能，并改善人类健康。

DESCRIPTION (provided by applicant): Quantitative imaging methods promise to improve the ability of cancer researchers to evaluate tumor burden and treatment response, but progress is thwarted by the lack of software infrastructure to record quantitative imaging information efficiently and reproducibly in the routine clinical workflow, and by the inability to store and share image metadata in standard formats. Many different quantitative imaging features that could more completely describe tumor burden are not being captured because collecting this information is laborious without tool support. Our objective is to develop software infrastructure that meets these needs of cancer researchers through three aims: (1) creating tools leveraging caBIG technologies to standardize quantitative imaging assessment of tumor burden. These tools will enable comprehensive and reproducible assessment of the quantitative imaging features of tumor burden as part of the routine clinical workflow and will improve the coordination of radiologists and oncologists in collecting quantitative image data. Through a commercial partnership, we will incorporate features of our tools in a commercial image interpretation workstation to introduce our methods into clinical practice; (2) developing methods to analyze quantitative image metadata and to help oncologists evaluate quantitative criteria on images collected as part of clinical trials; and (3) evaluating the utility of our infrastructure by applying our tools in two clinical trials and demonstrating the ability of our software infrastructure to quantitatively and more reproducibly measure tumor burden, helping researchers to assess the response to treatment in individual patients and patient cohorts. Our infrastructure will provide new ways of looking at quantitative imaging information related to treatment response along multiple dimensions so that researchers can recognize the effectiveness of treatments in clinical trials better and potentially sooner than using current unassisted approaches. Our work will accelerate quantitative imaging in cancer research, and will provide an essential complement to other centers in the Quantitative Imaging Network that focus on individual quantitative imaging methods. RELEVANCE: The methods and tools we develop will improve the ability of cancer researchers to collect and use quantitative imaging data to accurately assess tumor burden and to develop improved methods for evaluating whether treatment is effective. Improving the accuracy of quantitative imaging in assessing treatment response in individual patients will enable better treatment choices and improve human health.