Investigation of Neuregulin precessing by beta-site APP cleaving enzyme and gamma secretase in schizophrenia

精神分裂症（SCZ）是一种复杂的精神疾病，出现在男性和女性成年前后。到目前为止，还没有明确的病理症状来识别SCZ个体并将其置于特定的组中。一些蛋白质与这种疾病有遗传关系。我将研究这些蛋白质如何干扰人类大脑的功能。我最近发表的数据显示SCZ组大脑中的一种蛋白质减少。我的项目可能有助于开发新的、更有选择性的、副作用更少的疗法。

Schizophrenia (SCZ) is a complex psychiatric disorder that appears in male and female around adulthood. To date there is no clear pathological symptoms to identify SCZ individuals and place them in a specific group. Some proteins are genetically associated with this disease. I will investigate how some of these proteins disturb the function of the brain in human. My recent published data shows decrease of one of the proteins in the brain of SCZ group. My project may help develop novel and more selective therapies with less side-effects.