Investigation of Neuregulin precessing by beta-site APP cleaving enzyme and gamma secretase in schizophrenia

精神分裂症(SCZ)是一种复杂的精神障碍，在成年前后出现在男性和女性身上。到目前为止，还没有明确的病理症状来识别SCZ患者并将他们归入特定的组。一些蛋白质在基因上与这种疾病有关。我将研究其中一些蛋白质是如何干扰人类大脑功能的。我最近公布的数据显示，SCZ组大脑中的一种蛋白质减少。我的项目可能有助于开发新的、更具选择性、副作用更少的疗法。

Schizophrenia (SCZ) is a complex psychiatric disorder that appears in male and female around adulthood. To date there is no clear pathological symptoms to identify SCZ individuals and place them in a specific group. Some proteins are genetically associated with this disease. I will investigate how some of these proteins disturb the function of the brain in human. My recent published data shows decrease of one of the proteins in the brain of SCZ group. My project may help develop novel and more selective therapies with less side-effects.