University of Cape Town Clinical Trials Unit (UCTCTU)

描述（由申请人提供）：开普敦大学临床试验单位（UCTCTU）将成功地为美国国立卫生研究院和相关临床试验网络的科学需求做出贡献，原因如下：CTU提供了6个建立良好的多样化临床研究站点，由经验丰富的团队领导，并有能力在预防和治疗研究中应对艾滋病毒、结核病和相关疾病的流行，涉及广泛的人群，包括主要人群，如男同性恋者和青少年。临床研究点位于艾滋病毒、结核病、性传播感染和非传染性疾病负担与世界上任何地方一样高或更高的社区。两个临床研究地点已经开始了

DESCRIPTION (provided by the applicant): The University of Cape Town Clinical Trials Unit (UCTCTU) will successfully contribute to the scientific needs of the National Institutes of Health and associated Clinical Trial Networks for the following significant reasons: The CTU presents 6 well established diverse clinical research sites led by an experienced team and an ability to respond to the epidemics of HIV, TB and associated conditions in both prevention and treatment research involving a broad range of populations including key populations such as MSM and adolescents. The clinical research sites exist in communities where the burden of HIV, TB, STI and non-communicable disease are as high as or higher than anywhere in the world. Two of the clinical research sites are already DAIDS accredited and the other 4 are highly functional sites sponsored by a range of other well-recognized networks. The UCTCTU and its research sites occur in one South African province with a well-functioning, cooperative health department. The sites all have access to some of the best laboratories, and arguably the finest scientific expertise and best medical diagnostic and investigative resources in the country. The CTU is accommodated and supported by an institution ranked the best university in Africa and a Health Science faculty recently ranked in the top 50 worldwide. The efficiencies and synergies of this exciting and broad reaching consortium of clinical sites is invoked by the fact that all the sites are components of the University of Cape Town thus having a shared management platform and all sites and CTU core are within a short drive. In this re-application, the experienced team at the DTHC has extended collaborations to other well established clinical research groups in the Health Science Faculty at UCT and expanded the CTU to the proposed UCTCTU which will service 6 research sites and 5 networks with, in addition, an interest in antimicrobial resistance.