TRANSLATIONAL AIDS AND VIRAL PATHOGENESIS TRAINING

描述（由申请人提供）：这个T32支持的项目的目标是在加州洛杉矶大学（UCLA）培养传染病医学博士或医学博士/博士博士后研究员，从事HIV-1和其他病毒性疾病的转化发病机制研究。随着病毒性疾病（如HIV-1和病毒性丙型肝炎）的巨大全球疾病负担和基础科研的增加，开发成功疗法和疫苗的关键瓶颈是转化研究。因此，迫切需要合格的医生科学家研究人员谁可以从板凳上工作到床边。 鉴于加州大学洛杉矶分校在翻译/基础HIV-1研究和基础病毒学研究方面的整体实力，我们的培训计划主要集中在HIV-1上，研究员也有机会进行其他病毒的翻译发病机制研究。我们已经召集了一批经过精心挑选的教职员工，作为潜在的导师，跨越加州大学洛杉矶分校的几个部门。鼓励学员充分利用参与基础科学和临床教师之间的众多合作，以创造独特的转化研究机会。研究导师有积极的IRB协议，招募受试者进行HIV和HCV发病机制的研究，积极参与新型抗病毒疗法的人体试验，并正在研究HIV-1发病机制的几乎所有方面。许多教师导师也在研究其他病毒的基础病毒学，如丙型肝炎病毒和疱疹病毒。 我们的计划支持MD学员（导致博士学位）或MD/博士学员（寻求正式的博士后培训）作为其传染病专科培训的一部分， 医学部高级研究专业培训（星星）计划的贡献，提供结构化的科学和职业培训。这个T32培训计划每年支持一名合格的学员。我们为学员提供大量受保护的研究时间，以便他们可以发展独立的研究兴趣并获得独立的资金。该培训计划的最终目标是让我们所有的学员都能成为成功的独立调查员。由这个T32支持的前三年已经证明了我们在吸引高质量的实习医生方面的成功，并为他们提供了优秀的环境和资源，以发展基础转化病毒学研究的学术事业。

DESCRIPTION (provided by applicant): The goal of this T32-supported program is to train Infectious Diseases MD or MD/PhD postdoctoral fellows at University of California Los Angeles (UCLA) in translational pathogenesis research in HIV-1 and other viral diseases. With a huge global disease burden of viral diseases (such as HIV-1 and viral hepatitis C) and increasing basic scientific research, a key bottleneck for developing successful therapies and vaccines is translational research. There is therefore a pressing need for qualified physician-scientist researchers who can work from bench to bedside. Given the overall strength of UCLA in translational/basic HIV-1 research and basic virology research, our training program is predominately focused on HIV-1, with opportunities for fellows to pursue translational pathogenesis studies on other viruses as well. We have assembled a highly selected group of faculty members to serve as potential mentors, spanning several UCLA departments. Trainees are encouraged to take full advantage of the numerous collaborations between participating basic science and clinical faculty in order to create unique translational research opportunities. Research mentors have active IRB protocols to recruit subjects for the study of HIV and HCV pathogenesis, are actively involved with human trials for novel antiviral therapeutics, and are studying virtually all aspects of HIV-1 pathogenesis. Many faculty mentors are also studying fundamental virology of other viruses such as Hepatitis C Virus and Herpesviruses. Our program supports MD trainees (leading to a PhD) or MD/PhD trainees (seeking formal postdoctoral training) as part of their Infectious Diseases subspecialty training, with significant contribution from the Department of Medicine Specialty Training in Advanced Research (STAR) Program that provides structured scientific and career training. This T32 training program supports one well-qualified trainee each year. We provide trainees with significant protected research time so that they may develop independent research interests and secure independent funding. The ultimate goal of this training program is for all our trainees to succeed as independent investigators. The first three years supported by this T32 have demonstrated our success in drawing quality physician trainees and providing them with the outstanding environment and resources to develop academic careers in basic translational virologic research.