Characterization and Safety Profiling for Wireless LVADS

描述（由申请人提供）：LVAD治疗通过采用更小的旋转泵从根本上改善了充血性心力衰竭的生存率，与其更大的脉动式前辈相比，旋转泵表现出更高的可靠性和更低的发病率。经皮传动系统会导致感染，并因再次住院而增加发病率。早期基于经皮能量传输系统（TETS）的技术最初的热情迅速减弱，因为即使在几毫米范围内，功率输送的可靠性和效率也有限，而且存在对准问题。自由范围谐振电能输送（FREE-D）使用磁耦合谐振器将无线功率从患者穿戴的背心有效地传输到植入患者体内的LVAD。我们已经建立了一个强大的合作，以证明自由-D系统的可行性。我们已经在实验室中证明，该系统与轴流泵和磁悬浮系统一样工作良好，在几周内没有停电和不间断的性能。该系统在不同的功率要求下都是鲁棒的，并且在增加的距离下是稳定的。另外，角度未对准不会对系统效率或性能产生不利影响。目前的拨款申请是实现无线供电LVAD系统愿景的第一步。我们真诚地相信，我们将能够在我们先前工作的基础上开发出一个强大的无线电力传输平台。这样的电力输送系统将为我们的患者群体提供无数的优势，包括降低发病率，提高生活质量和改善长期生存率。

DESCRIPTION (provided by applicant): LVAD therapy has radically improved congestive heart failure survival by employing smaller, rotary pumps that demonstrated improved reliability and lower morbidity over their larger, pulsatile predecessors. Percutaneous drivelines lead to infections and increase morbidity due to re-hospitalizations. The initial enthusiasm over earlier Transcutaneous Energy Transfer Systems (TETS) based technologies rapidly waned due to limited reliability and efficiency of power delivery even over a few millimeters and problems with alignment. The Free-range Resonant Electrical Energy Delivery (FREE-D) uses magnetically coupled resonators to efficiently transfer wireless power from a vest worn by the patient to a LVAD implanted in their body. We have put together a strong collaboration to demonstrate the feasibility of the FREE-D system. We have demonstrated in the lab that the system works equally well with axial pumps and magnetically levitated systems with no power failure and uninterrupted performance over a period of weeks. The system is robust under differing power requirements and is stable at increasing distances. Additionally, angular misalignment does not have adverse effects on system efficiency or performance. The current grant application is the first step toward realizing our vision of a wirelessly powered LVAD system. We sincerely believe that we will be able to develop a robust platform for a wireless power delivery based on our prior work. Such a power delivery system will offer innumerable advantages to our patient population including lowered morbidity, better quality of life, and improved long-term survival.