VisualSonics Vevo 2100 micro-ultrasound upgrade for the RU in vivo Imaging Core

描述(由申请人提供)：比较生物科学中心的体内成像核心正在寻求升级我们现有的高频显微超声仪器。拟议的Visualsonics Vevo 2100高频微型超声升级将把现有的Vevo 770微型超声转变为动态研究工具，可满足NIH资助项目的六个实验室的研究需求。尽管我们的主要用户和次要用户的研究应用是不同的，但普遍需要使用小鼠疾病模型进行非侵入性纵向研究。拟议升级的Visualsonics Vevo 2100微超声平台将满足机构对先进的活体成像技术的需求，这些技术可用于以最佳方式加强心血管研究、急性和纵向癌症研究、小鼠肝脏疾病模型的表征以及肌肉消融和再生研究。升级后的微超声平台包含一系列新的和增强的功能：彩色多普勒(研究血流方向性和速度的能力)、利用非线性造影剂的能力、先进的 分析软件，如VevoSTrain(能够检测心血管壁运动异常)、可调节的焦深和卓越的分辨率(有助于肿瘤检测的特征)、执行显微超声图像的分屏分析的能力(增强通过纵向研究获得的数据的重复性的特征)以及 使用工厂预置和定制预置，这将使仪器更简单、更高效，并且更容易为新用户所访问。升级后的仪器将作为比较生物科学中心内的一个共享成像资源进行维护，并将在仪器使用期间得到该机构的支持。在洛克菲勒大学，Vevo 2100微型超声升级将被用于协助研究丙型肝炎病毒和丙型肝炎病毒感染后的肝脏疾病，肌肉消融和再生的研究，作为实现人类胚胎干细胞在小鼠胚胎皮质和脊髓中的异种移植的平台，加强对包括皮肤和毛发肿瘤在内的原发和转移性肿瘤疾病的研究，并作为成像工具研究纤维钙化性主动脉瓣狭窄和心肌梗死的啮齿心血管疾病模型，目的是为心脏病发作或中风患者开发新的治疗方法。

DESCRIPTION (provided by applicant): The In Vivo Imaging Core of the Comparative Bioscience Center is seeking to upgrade our current high- frequency micro-ultrasound instrumentation. The proposed VisualSonics Vevo 2100 high frequency micro- ultrasound upgrade will transition an existing Vevo 770 micro-ultrasound into a dynamic research tool that meets the research needs of six laboratories with NIH-funded projects. Although the research applications for our major and minor users are diverse, there is a common need to carry out noninvasive longitudinal studies using murine disease models. The proposed upgrade, the VisualSonics Vevo 2100 micro-ultrasound platform, will address an institutional need for advanced in vivo imaging technology that can be used to optimally enhance cardiovascular studies, acute and longitudinal cancer studies, the characterization of murine models of liver disease, as well as muscle ablation and regeneration studies. The upgraded micro-ultrasound platform contains an array of new and enhanced features: Color Doppler (the ability to study blood flow directionality and velocity), the ability to utilize nonlinear contrast agents, advanced analysis software such as VevoStrain (capable of detecting cardiovascular wall motion abnormalities), adjustable focal depth and superior resolution (features which aid in tumor detection), the ability to perform a split screen analysis of micro-ultrasound images (features which enhance the repeatability of data obtained over longitudinal studies), as well as the ability to use factory and customized presets which will make the instrumentation simpler, more efficient, and more readily accessible to new users. The upgraded instrument will be maintained as a shared imaging resource within the Comparative Bioscience Center and will be supported by the institution for the lifetime of the instrument. At The Rockefeller University the Vevo 2100 micro-ultrasound upgrade will be used to assist in the study of the hepatitis C virus and liver disease that occurs as a sequela to infection with the hepatitis C virus, the study of muscle ablation and regeneration, as a platform to enable xenotransplantation of human embryonic stem cells in the mouse embryonic cortex and spinal cord, to enhance the study of primary and metastatic neoplastic diseases, including skin and hair tumors, and as an imaging tool to study rodent cardiovascular disease models of fibrocalcific aortic valve stenosis and myocardial infarction with the goal of developing new therapies for heart attack or stroke victims.