Lifestyle Factors and Lymphoma: An Asia Cohort Consortium Pooling Project

描述(申请人提供)：非霍奇金淋巴瘤(NHL)是美国成年人中最常见的造血癌。在高加索人群中进行的研究表明，较高的体重和吸烟可能会增加患病风险，而饮酒可能会降低患病风险。然而，目前尚不清楚在历史上发病率低于高加索人的亚洲人群中是否存在同样的关系。鉴于肥胖和吸烟在亚洲许多国家和美国的移民日益普遍，迫切需要澄清这些可改变因素在非霍奇金淋巴瘤风险中的潜在作用。这项研究的目的是调查亚洲人群中淋巴瘤死亡与体重、吸烟和饮酒之间的关系。为了实现这些目标，我们将使用亚洲队列联盟的数据进行队列分析；该联盟包括17个队列，超过87万名参与者和686例记录的非霍奇金淋巴瘤死亡病例。关于体重、吸烟和饮酒的数据已经得到协调。关于非霍奇金淋巴瘤死亡和当前提案的人员时间的数据也已从每个队列中获得。我们将使用COX比例风险回归模型检验非霍奇金淋巴瘤死亡与体重、吸烟和饮酒之间的关系。将使用两阶段汇集数据分析方法来比较固定效应模型和随机效应模型的风险估计，以评估异质性的影响。利用亚洲队列联合会的现有数据，这项拟议的研究非常具有成本效益，可以澄清体重、吸烟和饮酒与非霍奇金淋巴瘤风险之间的关系，并将研究结果推广到亚洲人口，这是美国增长最快的种族之一。

DESCRIPTION (provided by applicant): Non-Hodgkin lymphoma (NHL) is the most common hematopoietic cancer among adults in the United States. Studies conducted in Caucasian populations suggested that a higher body mass and smoking may increase risk while alcohol use may lower the risk. However, it is not known whether the same relationships exist in Asian populations for which incidence rates historically have been lower than Caucasians. Given the rising prevalence of obesity and cigarette smoking in many countries in Asia and immigrants in the US, there exists an urgent need to clarify the potential role of these modifiable factors in th NHL risk. The aims of this research are to investigate the associations between deaths from lymphoma and body mass, smoking, and alcohol use in Asian populations. To accomplish these aims, we will conduct a cohort analysis using data from the Asia Cohort Consortium; consisting of 17 cohorts with over 870,000 participants and 686 recorded NHL deaths. Data on body mass, tobacco smoking, and alcohol use have already been harmonized. Data on NHL deaths and person time for the current proposal have also been obtained from each cohort. We will examine the association between deaths from NHL and body mass, smoking, and alcohol consumption using Cox proportional hazard regression models. A two- stage method for analysis of pooled data will be used to compare the risk estimates from fixed- effects models with those from random-effects models to assess the effect of heterogeneity. Using existing data from the Asia Cohort Consortium, the proposed study is extremely cost-effective for clarifying the relationship between body mass, smoking, and alcohol use and risk of NHL and extending findings to the Asian populations, one of the fastest growing ethnic groups in the United States.