LUNG TISSUE RESEARCH CONSORTIUM (LTRC) DATA COORDINATING CENTER

国家心肺血液研究所（NHLBI）肺组织研究联盟（LTRC）成立的主要目的是收集肺组织和血液样本，次要目的是收集慢性阻塞性肺疾病（COPD）、特发性肺纤维化（IPF）、慢性阻塞性肺疾病（COPD）患者的临床数据、有限暴露数据、生理学研究和放射学研究。其他相关的特发性间质性肺炎（IIP）和与结缔组织疾病相关的间质性肺炎，接受医学指示的肺切除术。为了进行比较，将收集需要肺切除术的对照受试者的肺组织和类似的临床数据。这些对照对象主要来自肺功能不佳的癌症患者，他们可以从结节或肿块中远程采集非肿瘤组织，也可能来自疑似间质性肺疾病（ILD）的患者，这些患者在病理检查后显示没有这种疾病。所有组织和血液标本以及临床数据将被储存起来，以供未来已批准研究计划并正在调查上述肺部疾病发病机制的研究者使用。

The National Heart, Lung and Blood Institute (NHLBI) Lung Tissue Research Consortium (LTRC) was established with the primary purpose of collecting lung tissue and blood samples and a secondary purpose of collecting clinical data, limited exposure data, physiologic studies, and radiographic studies from patients with chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), other related idiopathic interstitial pneumonias (IIP) and interstitial pneumonias associated with connective tissue diseases who undergo medically-indicated lung resection. For the purpose of comparison, lung tissue and similar clinical data will be collected from control subjects who require lung resection. These control subjects will primarily come from cancer patients without poor lung function for whom non-neoplastic tissue can be collected remotely from a nodule or mass and may also come from patients enrolled with suspected interstitial lung disease (ILD) who are shown after pathological examination not to have this disease. All tissue and blood specimens and clinical data will be banked and stored for distribution to future investigators who have approved study proposals and are investigating the pathogenesis of the aforementioned lung diseases.