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Improving the translational value of head and neck cancer patient-in-mouse models

提高头颈癌小鼠模型的转化价值

基本信息

批准号：
10598311
负责人：
RANDALL J KIMPLE
金额：
$ 6.56万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-01 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10598311
关键词：
Address Affect Age Animal Experimentation Animal Model Biological Biological Models Biology Cancer Model Cetuximab Clinical Clinical Trials Communication DNA Sequence Alteration DNA sequencing Data Educational process of instructing Evolution Generations Genetic Genetic Variation Goals HPV-negative head and neck cancer Head and Neck Cancer Histologic Human Human Biology Human Papillomavirus Immunocompetent Immunocompromised Host Immunotherapy Implant In Situ In Vitro Longevity Malignant Neoplasms Medical Mentors Methodology Methods Minority Graduate Student Modeling Molecular Mus Nose Operative Surgical Procedures Oral Organoids Outcome Parents Pathway interactions Patient Care Patient-Focused Outcomes Patients Physics Research Research Proposals Resistance Role Science Scientist Serial Passage Signal Pathway Site Skin Specimen Squamous Epithelium Squamous cell carcinoma Testing Therapeutic Studies Time Training Translating Treatment outcome Tumor Biology Use Effectiveness anticancer treatment base cancer therapy career cost expectation experience head and neck cancer patient human disease human model implantation improved improved outcome innovation mouse model novel novel therapeutics overtreatment patient derived xenograft model patient response pre-clinical pre-clinical research prevent programs radiation effect radiation response response single-cell RNA sequencing standard care subcutaneous targeted treatment therapy resistant translational model treatment effect treatment response tumor tumor microenvironment tumor-immune system interactions

项目摘要

Project Summary Patient-derived model systems are commonly used to study tumor biology and test novel treatments for head and neck cancer. Our goal is to improve the use of mammalian model systems of head and neck cancer to improve treatment outcomes for patients using valid, predictive, well characterized models. The goal of this supplement is to study cancer evolution and therapeutic response with rigorous assessment of tumor biology and genomic alterations to understand how choices made at the time of establishing models impact their relevance over time. Aim 1 will assess the role of heterotopic vs. orthotopic implantation on the therapeutic response and biology of the tumor. Aim 2 will test the concordance of response between patient-derived models and patients. We will use this supplement to support a minority graduate student in the medical physics program to study the effect of radiation on tumor evolution, to provide her with additional training in team science, mentoring, teaching, and communication to support her pursuit of an independent research career.

项目摘要患者衍生的模型系统通常用于研究肿瘤生物学和测试头部的新疗法和颈癌。我们的目标是改进头颈部癌症哺乳动物模型系统的使用，以使用有效的、可预测的、具有良好特征的模型改善患者的治疗结果。这样做的目的是补充内容是通过严格的肿瘤生物学评估来研究癌症的演变和治疗反应。和基因组改变，以了解在建立模型时所做的选择如何影响他们的随时间推移的相关性。目的1将评估异位植入与原位植入在治疗上的作用。肿瘤的反应和生物学。目标2将测试患者来源的反应的一致性模特和病人。我们将用这项补充来资助一名医学物理学的少数民族研究生。研究辐射对肿瘤进化的影响的计划，为她提供团队中的额外培训科学、指导、教学和交流，以支持她对独立研究事业的追求。