提高头颈癌小鼠模型的转化价值-猫眼课题宝

提高头颈癌小鼠模型的转化价值

批准号：

10598311

负责人：

RANDALL J KIMPLE

金额：

$6.56万

依托单位：

UNIVERSITY OF WISCONSIN-MADISON

依托单位国家：

美国

项目类别：

财政年份：

2021

资助国家：

美国

项目状态：

未结题

起止时间：

2021-07-01 至 2026-06-30

来源：

https://reporter.nih.gov/project-details/10598311

关键词：

Address Affect Age Animal Experimentation Animal Model Biological Biological Models Biology Cancer Model Cetuximab Clinical Clinical Trials Communication DNA Sequence Alteration DNA sequencing Data Educational process of instructing Evolution Generations Genetic Genetic Variation Goals HPV-negative head and neck cancer Head and Neck Cancer Histologic Human Human Biology Human Papillomavirus Immunocompetent Immunocompromised Host Immunotherapy Implant In Situ In Vitro Longevity Malignant Neoplasms Medical Mentors Methodology Methods Minority Graduate Student Modeling Molecular Mus Nose Operative Surgical Procedures Oral Organoids Outcome Parents Pathway interactions Patient Care Patient-Focused Outcomes Patients Physics Research Research Proposals Resistance Role Science Scientist Serial Passage Signal Pathway Site Skin Specimen Squamous Epithelium Squamous cell carcinoma Testing Therapeutic Studies Time Training Translating Treatment outcome Tumor Biology Use Effectiveness anticancer treatment base cancer therapy career cost expectation experience head and neck cancer patient human disease human model implantation improved improved outcome innovation mouse model novel novel therapeutics overtreatment patient derived xenograft model patient response pre-clinical pre-clinical research prevent programs radiation effect radiation response response single-cell RNA sequencing standard care subcutaneous targeted treatment therapy resistant translational model treatment effect treatment response tumor tumor microenvironment tumor-immune system interactions

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Project Summary Patient-derived model systems are commonly used to study tumor biology and test novel treatments for head and neck cancer. Our goal is to improve the use of mammalian model systems of head and neck cancer to improve treatment outcomes for patients using valid, predictive, well characterized models. The goal of this supplement is to study cancer evolution and therapeutic response with rigorous assessment of tumor biology and genomic alterations to understand how choices made at the time of establishing models impact their relevance over time. Aim 1 will assess the role of heterotopic vs. orthotopic implantation on the therapeutic response and biology of the tumor. Aim 2 will test the concordance of response between patient-derived models and patients. We will use this supplement to support a minority graduate student in the medical physics program to study the effect of radiation on tumor evolution, to provide her with additional training in team science, mentoring, teaching, and communication to support her pursuit of an independent research career.

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