The Ohio State University Pancreatic Disorders Network (OSU-PDN)

 描述(申请人提供)：慢性胰腺炎和T3cDM的诊断仍然是现代胃肠病学中两个最大的挑战和未满足的需求。来自俄亥俄州立大学的这份U01申请的重点是在美国的学术机构之间形成战略联盟。我们的主要目标是解决该联盟的研究目标和目的，并被视为临床中心。具体地说，我们a)描述俄亥俄州立大学胰腺疾病网络(OSU-PDN)，b)提出两项研究研究供联盟考虑，c)概述我们的临床和翻译研究基础设施。本组在CP和T3cDM中的几个关键实验观察证实[OSU-PDN]和验证[CSCPDPC-CCS]：1)CP患者的胰液(Pf)和尿液(U)的蛋白质组学分析显示，与健康对照组相比，几种胰液蛋白-SERPINA5、ANXA5、CST3(候选胰液标记物)和尿蛋白-CPN2、A1AG1、AMYP(候选尿标记物)发生了显著的倍增变化；2)混合膳食对血清胰多肽反应的显著差异可能有助于将T3cDM与更常见的T2 DM区分开来。这些初步观察结果是我们研究建议的重点，供财团指导委员会审议。我们的临床中心将由俄亥俄州立大学临床与转化科学中心(CCTS/CTSA)与来自我们在俄亥俄州立大学-PDN和联盟中的“网络合作伙伴”的其他CTSA合作进行集中协调。CCTS/CTSA提供咨询服务以及临床和转化性研究基础设施。这一独特的资源将帮助我们的团队与CDMC、DSMB和NIDDK中央存储库进行沟通。我们网络的这两项研究建议都解决了NIDDK-国家消化疾病委员会概述的对慢性胰腺炎、糖尿病和胰腺癌的知识和理解方面的差距，并与慢性胰腺炎、糖尿病和胰腺癌临床中心研究联盟(CSCPDPC-CCS)的目标保持战略一致(U01)。

 DESCRIPTION (provided by applicant): The diagnosis of chronic pancreatitis and T3cDM remain two of the greatest challenges and unmet needs in modern gastroenterology. The focus of this U01 application from The Ohio State University is to form a strategic alliance among academic institutions in the United States. Our major goals are to address the research objectives and aims of the Consortium, and to be considered as a clinical center. Specifically, we a) describe The Ohio State University Pancreatic Disorders Network (OSU-PDN), b) propose two research studies for consideration by the Consortium and c) outline our clinical and translational research infrastructure. Several key experimental observations from our group in CP and T3cDM warrant confirmation [OSU- PDN] and validation [CSCPDPC-CCs] : 1) Proteomic analysis of pancreas fluid (PF) and urine (U) in CP subjects revealed statistically significant fold-changes in several pancreatic fluid proteins - SERPINA5, ANXA5, CST3 (candidate pancreatic fluid markers) and urine proteins - CPN2, A1AG1, AMYP (candidate urine markers) when compared to healthy controls and 2) A significant difference in serum pancreatic polypeptide response to a mixed meal was observed that may distinguish T3cDM from the much more prevalent T2DM. These preliminary observations are the focus of our research proposals for consideration by the Consortium Steering Committee. Our Clinical Center will be centrally coordinated by the Ohio State University Center for Clinical and Translational Science (CCTS/CTSA) in collaboration with other CTSAs from our "network partners" in the OSU-PDN and the Consortium. The CCTS/CTSA provides consulting services and access to clinical and translational research infrastructure. This unique resource will assist our team in communicating with the CDMC, DSMB and NIDDK central repository. Both research proposals from our network address gaps in knowledge and understanding of chronic pancreatitis, diabetes and pancreas cancer as outlined by the NIDDK- National Commission on Digestive Diseases, and are strategically aligned with the objectives of the Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer Clinical Centers (CSCPDPC-CCs) (U01).