Prolonged Overnight Fasting for Reducing Breast Cancer Risk

描述（由申请人提供）：此F31提案具有广泛的培训活动，指导和研究项目计划，将为我提供所需的支持，知识和技能，以实现我的职业目标，成为肥胖，代谢和癌症预防/生存领域的独立调查员。 我的教育背景，培训历史和研究活动表明，对实现这些职业目标的持续承诺和进展。我在劳伦斯大学获得了生物化学的本科学位，在罗切斯特的马约诊所完成了一系列分子生物学的本科研究奖学金，并在国家糖尿病、消化和肾脏疾病研究所（NIH临床中心）完成了能量平衡和人类营养/代谢的博士前奖学金。我目前是圣地亚哥州立大学/加州大学圣地亚哥分校（UCSD）健康行为（公共卫生）联合博士课程的博士生，也是Moores UCSD癌症中心的研究生。拟议的F31培训奖学金的总体目标是使我能够从我以前的生物化学，人体代谢和乳腺癌预防的培训经验，通过探索饮食模式如何影响乳腺癌风险的代谢途径。 拟议的培训计划将使我获得以下领域的先进知识和技能：（1）将肥胖，糖尿病和生活方式与致癌联系起来的生物机制，（2）用于分析生物变量和调查数据的高级统计学，（3）科学写作和沟通，以及（4）网络和职业发展。UCSD是我追求这些目标的理想环境，由于其非常强大的生活方式和癌症研究人员群体，以及NCI资助的能量学和癌症跨学科研究（TREC）中心的存在。值得注意的是，来自Moores UCSD癌症中心的研究人员领导了女性健康饮食和生活（WHEL）研究，该研究为涉及乳腺癌幸存者的拟议分析提供了数据。 F31奖提供的支持将为我提供受保护的时间，以扩大我的研究重点，并发展数据分析和科学写作方面的高级技能。本建议书中描述的培训活动和研究项目将补充我以前的研究和培训经验，并使我能够加深对生活方式因素之间关系的认识和理解（即，禁食持续时间）和癌症发展的代谢途径。

DESCRIPTION (provided by applicant): This F31 proposal features a wide-ranging program of training activities, mentorship, and research projects that will provide me with the support, knowledge, and skills needed to progress towards my career goal of becoming an independent investigator in area of obesity, metabolism, and cancer prevention/survivorship. My educational background, training history, and research activities demonstrate a continued commitment and progression towards achieving these career goals. I received my undergraduate degree in Biochemistry from Lawrence University, completed a series of undergraduate research fellowships in molecular biology at Rochester's Mayo Clinic, and completed a pre-doctoral fellowship in energy balance and human nutrition/metabolism with the National Institute of Diabetes and Digestive and Kidney Diseases (NIH Clinical Center). I am currently a doctoral student in the San Diego State University/University of California,San Diego (UCSD) joint Doctoral Program in Health Behavior (Public Health), and research student at the Moores UCSD Cancer Center. The overall objective of the proposed F31 training fellowship is to enable me to build from my previous training experiences in biochemistry, human metabolism, and breast cancer prevention, by exploring how dietary patterns influence metabolic pathways of breast cancer risk. The proposed training plan will allow me to gain advanced knowledge and skills in the following areas: (1) biologic mechanisms that link obesity, diabetes, and lifestyle t carcinogenesis, (2) advanced statistics for analysis of biological variables and survey data, (3) scientific writing and communication, and (4) networking and career development. UCSD is the ideal environment for me to pursue these goals, due to its exceptionally strong group of lifestyle and cancer researchers, and the presence of an NCI-funded Transdisciplinary Research on Energetics and Cancer (TREC) Center. Notably, investigators from the Moores UCSD Cancer Center led the Women's Healthy Eating and Living (WHEL) study, which is providing data for the proposed analyses involving breast cancer survivors. The support provided by an F31 award will provide me with the protected time to expand my research focus and develop advanced skills in data analysis and scientific writing. The training activities and research projects described in this proposal will complement my previous research and training experiences and enable me to deepen my knowledge and understanding of the relationships between lifestyle factors (i.e., fasting duration) and metabolic pathways of cancer development.