Core Center for Quantitative Neuroscience with Magnetic Resonance (QNMR)

描述（由申请人提供）：最先进的MRI/MRS技术是最强大的体内脑结构和功能成像方法之一。但是，由于技术和专业知识的入门成本过高，研究活体动物模型的神经科学家采用MRI/MRS的速度很慢。耶鲁大学的定量神经科学与磁共振（QNMR）核心中心为耶鲁大学和附近机构的神经科学pi提供访问和支持，进行跨学科的基于核磁共振的神经科学研究。资源包括几个高场，小而宽，水平孔磁铁以及射频（RF）线圈工程的相关资源，复杂手术和输液的辅助设施和技术支持，设备齐全的生化和材料科学实验室，几个进行体内电学和光学研究的神经生理学平台，先进的数据处理设施，分布式计算和存档。QNMR核心中心由四个协同模块组成，每个模块都致力于提高跨学科神经科学研究的有效性，包括MRI（核心1）、MRS（核心2）、神经生理学（核心3）和数据分析（核心4）。每个核心的目标是(i)实施，维护和支持神经科学pi的核心方法；（ii）支持使用Core方法的新研究计划；（iii）为神经科学pi及其员工提供培训和指导；（iv）整合协同使用MR/神经生理学测量和pl特异性数据分析；(v)实施新的核心方法来支持神经科学pi；（vi）跟踪核心活动并向NIH社区传播/共享资源。QNMR核心中心的总体目标是通过促进神经科学家使用先进的MR和MR/电/光学相结合的方法，并通过向NIH社区传播发现和改进的方法，加强nds和NIH资助的研究。

DESCRIPTION (provided by applicant): State-of-the-art MRI/MRS techniques are among the most powerful in vivo methods for imaging brain Structure and function. But adoption of MRI/MRS by neuroscientists working with in vivo animal models has been slow due to excessive entry costs of technology and expertise. Yale's Quantitative Neuroscience with Magnetic Resonance (QNMR) Core Center provides access and support to neuroscience PIs, at Yale and nearby institutions, for cross-disciplinary MR-based neuroscience studies. The resources include several high-field, both small and wide, horizontal-bore magnets as well as related resources for radio-frequency (RF) coil engineering, auxiliary facilities and technical support for complex surgeries and infusions, fully equipped biochemical and material science laboratories, several neurophysiological rigs to conduct in vivo electrical and optical studies, an advanced data processing facilities with distributed computing and archiving. The QNMR Core Center consists of four synergistic modules, each dedicated to improving effectiveness of ongoing research based upon cross-disciplinary neuroscience studies involving MRI (Core 1), MRS (Core 2), neurophysiology (Core 3), and data analysis (Core 4). The aims for each Core are to (i) implement, maintain, and support the Core methods for neuroscience PIs; (ii) support new research initiatives using Core methods; (iii) train and provide mentorship for neuroscience PIs and their staff; (iv) integrate synergistic use of MR/neurophysiological measurements and Pl-specific data analysis; (v) implement new Core methods to support neuroscience PIs; and (vi) track Core activities and disseminate/share resources to NIH community. The overall goal of the QNMR Core Center is to enhance NINDS- and NIH-funded research through facilitating the use of neuroscientists of advanced MR and combined MR/electrical/optical methods and through dissemination of discoveries and improved methodologies to the NIH community at large.