A wearable asthma trigger monitoring system with integrated physiological monitor

 描述(申请人提供)：哮喘是一种慢性炎症性呼吸道疾病，会导致间歇性症状恶化，对患者的健康造成巨大负担，如果控制不好，可能会危及生命。尽管在哮喘的药物治疗方面取得了进展，但总体上哮喘控制仍然不令人满意。虽然触发避免被认为是哮喘自我管理的一个关键因素，而且已经开发和分发了详细的触发避免模块，但它们的实际实施取得了好坏参半的结果。问题在于潜在诱因的多样性，缺乏对诱因的系统监测，以及对低碳酸血症等情况的低调生理监测仍然缺失。这项提议的目标是开发一个全面的监测系统，以便能够同时监测哮喘症状和/或恶化的关键环境诱因以及儿童哮喘患者的实时生理状态。这将为患者提供有关他们瞬间触发暴露的客观信息，有可能指导个性化的触发避免策略，并将更好地为研究提供关于日常生活中哮喘症状/恶化的潜在因素的信息。我们已经组建了一支由工程师、医生和健康心理学家组成的独特的、紧密联系的多学科团队。在项目的所有阶段，我们还将得到一个强大的外部咨询委员会和NIBIB的项目工作人员的指导并与其密切合作。

 DESCRIPTION (provided by applicant): Asthma is a chronic inflammatory airway disease that leads to episodic symptom exacerbations, which extoll a substantial burden on the patients' well-being and can be life threatening if not controlled adequately. Despite progress in the pharmacological treatment of asthma, overall asthma control remains unsatisfactory. Although trigger avoidance is recognized as a key element of asthma self-management, and elaborate trigger avoidance modules have been developed and distributed, their actual implementation has had mixed success. Problems lie in the variety of potential triggers, lack of systematic monitoring of triggers, and unobtrusive physiological monitors for conditions like hypocapnia are still missing. The goal of this proposal is to develop a comprehensive monitoring system that will allow simultaneous monitoring of critical environmental triggers of asthma symptoms and/or exacerbations as well as real-time physiological status of pediatric asthma patients. This will provide patients with objective information about their momentary trigger exposure with the potential to guide personalized trigger avoidance strategies and will better inform research about the factors that underlie asthma symptoms/exacerbation in daily life. We have assembled a unique and closely knit multidisciplinary team of engineers, physicians, and health psychologists. We will also be guided by and work closely with a strong External Advisory Committee and program staff at the NIBIB at all stages of the project.