Animal Reagent and Immune Function Core

动物模型试剂和免疫功能-核心B 严重的脓毒症是一个主要的公共卫生问题，因为它是住院患者的主要死亡原因。 美国的患者，发达国家的十大主要死亡原因之一。七十 百分之百的败血症患者存活下来，但通常不会恢复到病前的状态。最近的证据 表明败血症幸存者经历了认知和免疫功能障碍，超过一半的 幸存者在5年内死亡。动物、试剂和免疫功能核心将提供一个集中的 用于进行动物手术、产生细胞因子和抗体试剂以及监督的资源 免疫功能评估测试。在这里提出的研究中使用这些动物模型和试剂将 提供重要数据，可用于调节神经和免疫功能，以开发治疗 脓毒症引起的认知和免疫损伤的预防和治疗方法。 相关性(见说明)； 这个核心将有助于小鼠的手术和免疫功能的测试。它会产生细胞因子和抗体 适用于所有研究项目。

Animal Model Reagent, and Immune Function - Core B Severe sepsis is a major public health problem, because it is the leading cause of death in hospitalized patients in the United States, and one of the ten leading causes of death in the developed world. Seventy percent of the sepsis patients survive, but often do not return to their premorbid condition. Recent evidence indicates that sepsis survivors experience cognitive and immune impairment, and more than half of the survivors die within 5 years. The Animal, Reagent and Immune Function Core will provide a centralized resource for performing animal surgeries, generating cytokine and antibody reagents, and overseeing immune function assessment tests. Use of these animal models and reagents in studies proposed here will provide significant data that can be used to modulate neural and immune function to develop therapeutic modalities for the prevention and treatment of sepsis induced cognitive and immune impairments. RELEVANCE (See instructions); This Core will help in mouse surgery and in tests of immune function. It will produce cytokines and antibodies for all research projects.