Investigation into the roles of Ena/VASP-Like and Protein Phosphatase 4C in DNA damage repair via homologous recombination
Investigation into the roles of Ena/VASP-Like and Protein Phosphatase 4C in DNA damage repair via homologous recombination
批准号:
nhmrc : 1093995
负责人:
Mr Christian Jekimovs
金额:
$3.81万
依托单位国家:
澳大利亚
项目类别:
Postgraduate Scholarships
财政年份:
2015
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2015-01-01 至 2017-12-31
中文摘要
DNA损伤的修复是确保基因组稳定性的关键细胞机制。本项目旨在通过同源重组研究Ena/VASP样蛋白和蛋白磷酸酶4C在DNA损伤修复中的作用。DNA损伤反应途径是癌症和衰老研究的重要领域,PP 4C和EVL在同源重组中的潜在作用需要进一步研究。
英文摘要
The repair of DNA damage is a critical cellular mechanism that exists to ensure genomic stability. This project aims to investigate the role of the proteins Ena/VASP-Like and Protein Phosphatase 4C in DNA damage repair via homologous recombination. The DNA damage response pathway is an important area in the study of cancer and ageing, and the potential role of PP4C and EVL in homologous recombination needs to be investigated further.
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