WHONET: Tools for a Global Microbial Sensor Network

描述（由申请人提供）：传染病和对抗菌剂的耐药性对全球人类和动物福利构成威胁，并消耗有限的资源。为了控制和管理感染性微生物及其耐药基因，我们需要知道它们在哪里，它们要去哪里。全世界数以万计的微生物实验室每天向医疗保健提供者报告结果，应被视为传染病传感器，是了解世界不断变化的微生物种群的丰富哨兵窗口。为了支持收集、整合和解释来自不同数据源的数据，我们世卫组织抗菌素耐药性监测合作中心的团队与世界卫生组织合作开发和传播WHONET软件已有24年。WHONET是领先的免费公共卫生软件，支持基于实验室的抗菌素耐药性监测，并支持110多个国家和2500家医院，公共卫生，食品和动物实验室的监测活动。在我们目前的资助中，我们成功地将WHONET的传统桌面版本现代化为一个安全的多层网络架构，用于数据管理，分析和演示。有了这个更成熟的平台，赠款的延续将使WHONET的范围和影响扩大到一些领域：1）从新的分子技术中获取数据，迅速改变常规的微生物学实践; 2）改进工具，用于识别，地理跟踪，以及从经典和新的分子表型方法中自动护理，感染预防和公共卫生警报微生物亚型; 3）数据访问和传输的额外安全选项;以及4）在合作伙伴网络中的试点实施。菌株表型的改进定义将利用经典的统计和更新的数据挖掘技术，这些技术是由EpiInfo、R和Weka例程集成到WHONET分析模块中提供的。在过去的几年中，WHONET发展的一个令人兴奋的新方向是有针对性地扩展功能，以支持基于实验室的医疗相关感染的公共卫生报告，最值得注意的是CDC国家医疗安全网络（NHSN）的MDRO/CDI模块。这需要为患者移动（“入院/出院/转院”）和选择性临床数据元素添加新的数据源。美国和国际感染预防的同事越来越多地要求在WHONET中包含额外的感染报告模块，特别是CLABSI，CRANTI和SSI，我们将通过此应用程序完成。微生物在人、医院、动物、大陆之间移动并进化。通过自动化，实时动员和警惕丰富但基本上未开发的资源-世界微生物实验室的累积努力-我们的目标是在公共部门开发免费的解决方案，可以在世界范围内应用，以动员，共享和解释 这些数据可以指导及时有效的公共卫生行动。

DESCRIPTION (provided by applicant): Infectious diseases and resistance to antimicrobial agents grow as threats to human and animal welfare worldwide and drain limited resources. To contain and manage infecting microbes and their resistance genes, we need to know where they are and where they are going. Tens of thousands of microbiology laboratories worldwide reporting results daily to healthcare providers should be viewed as infectious disease sensors, rich sentinel windows into the world's evolving microbial populations. To support the collection, integration, and interpretation of data from disparate data sources, our team at the WHO Collaborating Centre for Surveillance of Antimicrobial Resistance has developed and disseminated the WHONET software for 24 years in collaboration with the World Health Organization. WHONET is the leading free public health software to support laboratory-based surveillance of antimicrobial resistance, and supports surveillance activities in over 110 countries and 2500 hospital, public health, food, and animal laboratories. In our current grant, we have successfully modernized the legacy desktop version of WHONET into a secure, multi-tiered web architecture for data management, analysis, and presentation. With this more mature platform, a grant renewal would permit the expansion of WHONET's scope and impact in a number of areas: 1) data capture from new molecular technologies rapidly transforming routine microbiological practices; 2) improved tools for recognition, geo-tracking, and automated caregiver, infection preventionist, and public health alerts of microbial subtypes from both classic and new molecular phenotyping methods; 3) additional security options for data access and transfer; and 4) pilot implementation in partner networks. The improved definition of strain phenotypes will leverage classical statistical and newer data mining techniques offered by the integration of EpiInfo, R, and Weka routines into the WHONET analysis module. In the past few years, an exciting new direction for WHONET development has been the targeted expansion of capabilities to support laboratory-based public health reporting of healthcare-associated infections, most notably the MDRO/CDI module of the CDC National Healthcare Safety Network (NHSN). This has required the addition of new data feeds for patient movements ("Admission/Discharge/Transfer") and selective clinical data elements. U.S. and international infection prevention colleagues increasingly request the inclusion within WHONET of additional infection reporting modules, especially CLABSI, CAUTI, and SSI, which we will accomplish with this application. Microbes move - between people, hospitals, animals, continents - and evolve. Through automated, real-time mobilization and vigilance of a rich yet largely untapped resource - the cumulative efforts of the world's microbiology laboratories - our goal is the development of free solutions in the public sector that can be applied worldwide to mobilize, share, and interpret these data to guide timely and effective public health action.