FASEB SRC on Molecular Mechanisms and Physiological Consequences of Protein Aggregation

 描述(申请人提供)：虽然淀粉样蛋白长期以来一直是许多神经系统疾病的标志，但控制淀粉样蛋白形成的确切分子途径，这些事件在疾病发生和发展中的因果关系，以及这些过程对治疗中断的敏感性，仍然是积极研究的重要开放问题。这份R13提案寻求对FASEB夏季研究会议“蛋白质聚集的分子机制和生理后果”的核心支持。我们的计划是1995年开始的系列会议中的第十次，我们的计划寻求利用可用的蛋白质、系统和方法的广度来促进我们对与淀粉样变相关的全面生物学现象的理解，目标是最终干预这些过程。会议将于2015年6月21日至26日在佛罗里达州棕榈滩举行，将提供一个论坛，介绍和讨论新出现的进展，并建立合作关系，以应对该领域的重大挑战。这次会议的规模很小(通常是150人)，它创新性地代表了淀粉样蛋白发生的全方位研究，为捕捉和整合这一过程的复杂性并协同推进该领域提供了一个独特的机会。

 DESCRIPTION (provided by applicant): While amyloid has long been the hallmark of many neurological diseases, the precise molecular pathways governing amyloid formation, the causality of these events in disease initiation and progression, and the sensitivity of these processes to therapeutic disruption, remain significant open questions that are the subject of aggressive research. This R13 proposal seeks core support for a FASEB Summer Research Conference on "Molecular Mechanisms and Physiological Consequences of Protein Aggregation." The tenth conference in a series that began in 1995, our program seeks to leverage the breadth of proteins, systems, and approaches available to advance our understanding of the full range of biological phenomena linked to amyloidogenesis with the goal of ultimately intervening in these processes. The conference will be held in Palm Beach, FL on June 21-26, 2015, will provide a forum for the presentation and discussion of newly arising advances and for establishing collaborative relationships to address the grand challenges in the field. The small size (typically 150 participants) of this conference and its innovative representation of the full range of research on amyloidogenesis provides a unique opportunity to capture and integrate the complexity of this process and synergistically advance the field.