Research and Development of Novel Drug Delivery Systems Symposium

 描述（由申请人提供）：高通量筛选和新治疗靶标的出现导致发现具有纳摩尔功效的高效分子。新治疗剂的临床转化受到不良理化和生物制药性质的限制。为了解决这一潜在的挑战，现在需要学术界、制药业和监管机构共同努力，开发新型的给药系统。几种新的药物疗法由于非选择性药物处置、对细胞内靶点的可及性差、剂量限制脱靶效应和药物毒性而失败。 长期给药的抵抗力。这些限制可以通过开发和扩大新型药物递送技术来克服。为了加快新分子的翻译，本次会议的目的是在药物开发的主要参与者之间分享有关药物开发原则的知识，包括来自学术界，工业界和监管机构的代表。预计将有不同群体的个人参加，包括那些代表少数群体和传统上代表性不足的社区的科学事业。为期两天的研讨会将包括口头以及海报介绍。为这次会议提供的财政支持将为学生创造与药物输送领域顶级科学家互动的机会。此外，还将提供登记费减免和旅费奖励，以鼓励少数群体和代表性不足的社区参与。根据会议上的发言和讨论，将在会议结束后3个月内编写一份手稿，并及时提交出版。

 DESCRIPTION (provided by applicant): High throughput screening and emergence of new therapeutic targets led to discovery of highly potent molecules with nanomolar efficacy. Clinical translation of the new therapeutic agents is limited by poor physicochemical and biopharmaceutical properties. To resolve this potential challenge, the need of the hour is the concerted effort by academia, pharmaceutical industry and regulatory body towards the development of novel delivery systems. Several new drug therapies fail due to non- selective drug disposition, poor accessibility to intracellular targets, dose limiting off target effects and resistance upon prolonged administration. These limitations can be potentially overcome through the development and scale up of novel drug delivery technologies. To expedite the translation of new molecules, the purpose of this conference is to share knowledge on drug product development principles among key players of pharmaceutical drug development, including representatives from academia, industry, and regulatory agencies. Participation from a diverse group of individuals including those representing minorities and traditionally underrepresented communities in science careers is expected. The two day symposium will include oral as well as poster presentations. Financial support provided for this conference will create opportunity to students to interact with top scientist in the field of drug delivery. In addition, registration fee waivers and travel awards will be provided to encourage participation by minorities and underrepresented communities. Based on the presentations and discussions at the conference, a manuscript will be prepared within 3 months after the conference and submitted for publication in a timely manner.