Iron Metabolism and Liver Disease

首席调查员作为一个团队工作了20年，这是NHMRC项目资助的一部分，该项目连续三次更新，随后在NHMRC对QIMR的整体资助下获得了成功。他们的综合专业知识涵盖了从床边到工作台的整个范围，涉及铁稳态的临床研究和基础分子研究。铁稳态和铁过载的共同主题几乎贯穿了该团队的所有研究。该团队的研究导致了对铁调节和体内平衡的基本观察，并制定了血色素沉着病的管理和筛查指南，血色素沉着病被认为是高加索人群中最常见的遗传性疾病。拟议的研究包括旨在破译铁吸收和运输机制的分子研究；这些过程是如何调节的；以及诊断为血色病患者的临床研究。研究结果对血色病的诊断、管理和预防具有重要意义。

The Chief Investigators have worked as a team for 20 years as part of a successful NHMRC Program Grant that was renewed on three successive occasions and subsequently under a NHMRC Block Grant to QIMR. Their combined expertise covers the whole spectrum from the bedside to the bench with respect to clinical studies and fundamental molecular studies of iron homeostasis. The common theme of iron homeostasis and iron overload pervades virtually all the research of the team. The team�s research has led to fundamental observations of iron regulation and homeostasis and the development of guidelines for the management of, and screening for, haemochromatosis, recognized as the most common inherited disorder of Caucasian populations. The proposed research encompasses molecular studies aimed at deciphering the mechanisms of iron absorption and transport; how these processes are regulated; and clinical studies on patients diagnosed with haemochromatosis. The findings are particularly pertinent to the diagnosis, management and prevention of clinical haemochromatosis.