Iron overload mechanisms in dyserythropoietic anaemias and therapeutic targets at the ERFE gene locus

铁负荷过重会导致器官功能障碍和发病率，这些人患有红细胞疾病，如地中海贫血，或由于癌症或骨髓衰竭而需要长期输血。一种主要的控制化合物红铁酮影响铁代谢的方式尚不清楚。我们的项目将使用分子方法来确定红铁蛋白基因如何参与导致红细胞疾病中的铁超载，并可能开辟更好的管理途径。

Iron overload causes organ dysfunction and morbidity for people who have red blood cell disorders such as thalassemia, or chronic transfusion requirements due to cancer or bone marrow failure. The manner in which a principal controlling compound, erythroferrone, influences iron metabolism is undefined. Our project will use molecular approaches to determine how the erythroferrone gene is involved in causing iron overload in red cell disorders and potentially open better management pathways.