NINDS Biomarker Repository

 描述(由申请人提供)：我们提出了一种全面的方法来建立符合RFA-NS-15-010中列出的所有要求的NINDS人类生物标记物生物样本和数据存储库。印第安纳大学目前拥有阿尔茨海默病、帕金森氏病和脑震荡研究领域的关键知识库。我们已经建立了一个强大的管理结构，确保生物储存库功能的所有方面都得到良好的设计和维护。所有流程均由标准操作程序驱动，确保所有级别的一致性。我们将以我们成功的生物库经验为基础，与NINDS资助的所有团体以及合作伙伴组织建立牢固的伙伴关系。这将确保为NINDS生物标记库开发一种全面的生物库方法，使样本能够满足未来研究的需要。这一努力的成功将通过我们协调多个相关生物信息库的需求的能力来最大化 就在印第安纳大学。根据我们过去在建立广泛使用的生物标记物储存库方面的成功，我们建议在NINDS和科学联络委员会的监督下，实现以下具体目标：目标1：建立一个强有力的行政结构，对NINDS生物标记物储存库的所有方面进行监督。目标2：创建和维护一个最先进的生物样品储存库，接收、处理和存储来自经批准的研究的所有样本。目标3：协调NINDS生物标记库的所有数据管理和基于网络的活动。

 DESCRIPTION (provided by applicant): We propose a comprehensive approach to the NINDS Human Biomarkers Biospecimen and Data Repository that will fulfill all requirements listed in RFA-NS-15-010. Indiana University currently houses key repositories in the areas of Alzheimer's disease, Parkinson's disease and concussion research. We have developed a strong administrative structure that ensures that all aspects of biorepository function are well designed and maintained. All processes are driven by standard operating procedures, ensuring uniformity at all levels. We will build on our successful biorepository experience to create a strong partnership with all groups funded by NINDS as well as partner organizations. This will ensure that a comprehensive approach to biobanking is developed for the NINDS Biomarker Repository that will allow samples to meet the needs of future research. The success of this effort will be maximized by our ability to coordinate the needs of multiple related biorepositories housed here at Indiana University. Based on our past success in establishing widely used biospecimen repositories, we propose under the oversight of NINDS and the Scientific Liaison Committee, the following specific aims: Aim 1: Establish a strong administrative structure that will oversee all aspects of the NINDS Biomarker Repository. Aim 2: Create and maintain a state-of-the-art biospecimen repository that receives processes and stores all samples from approved studies. Aim 3: Coordinate all data management and web-based activities of the NINDS Biomarker Biorepository.