MacMillan: Coordination and Dissemination; Center for High-Throughput Functional Annotation of Natural Products: Coordination and Dissemination (Macmillian)

翻译后摘要：中心的高产量功能诠释的天然产品， 数据生成、数据分析和信息学的优势， 来自UTSW和UCSC的天然产品领域，以帮助生产大规模的 分子和化学注释植物和天然产物。该中心基于 在正交表型筛选平台上， 化合物、提取物和馏分。我们的成果将是数据和数据分析 管道，这将有助于确定植物和天然药物的作用机制 产品和帮助表明潜在的治疗应用新的天然产品- 衍生化合物。这些数据研究平台需要高水平的 网络内部协调，与更大的植物和天然产品整合 社区，以及植物和膳食补充剂的消费者。协调 建议的传播部分，连同行政核心， 负责科学团队的整合和数据的及时发布。内部- 网络协调将通过月度和年度会议进行管理， 我们的技术示范项目合作者和外部咨询委员会 以及建立基于网络的可检索数据库。我们的中心与 植物和天然产品社区以及植物消费者将 由一个高度动态的网站驱动，该网站提供对我们的主要数据、分析 以及我们评估的化学物质的摘要。

Abstract: The Center for High-Throughput Functional Annotation of Natural Products has been assemble to unite the data generation, data analytics and informatics strengths in the field of natural products from UTSW and UCSC to help produce a broad-scale molecular and chemical annotation botanicals and natural products. The Center is based on orthogonal phenotypic screening platforms that generate functional signatures for compounds, extracts and fractions. Our deliverable will be a data and data analytics pipeline that will help define the mechanism(s) of action of botanicals and natural products and help indicate potential therapeutic applications for novel natural product- derived chemical compounds. These data research platforms require a high level of intra-network coordination, integration with the greater botanical and natural product community, and with consumers of botanical and dietary supplements. The coordination and dissemination portion of the proposal, in conjunction with the administrative core is responsible for integration of the scientific team and a timely release of data. The intra- network coordination will be managed through monthly and yearly meetings that involve our Technology Demonstration Project collaborators and an External Advisory Board and the establishment of web-based searchable database. Integration of our Center with the botanical and natural product communities as well as botanical consumers will be driven by a highly dynamic website that provides access to our primary data, analysis and summaries of the chemical entities we evaluate.