MacMillan: Administrative Core; The Center for High-Throughput Functional Annotation of Natural Products Administrative Core (Macmillian)

麦克米伦：行政核心；

• 批准号: 8881712
• 负责人: JOHN B MACMILLAN
• 金额: $ 5.4万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8881712
• 关键词: Bioinformatics; Biological; Biological Factors; Biomedical Research; Botanicals; Cells; Chemicals; Collaborations; Communities; Community Outreach; Complex Mixtures; Data; Data Set; Generations; Goals; Grant; Leadership; Libraries; Medical center; Metadata; Methods; Natural Products Chemistry; Reporting; Research; Resources; Technology; Texas; Therapeutic; United States National Institutes of Health; Universities; Validation; abstracting; biological systems; data sharing; dietary supplements; expectation; innovation; interdisciplinary approach; meetings; multidisciplinary; new technology; novel; programs; research and development; screening; technology development; tool

Abstract: The Center for High-Throughput Functional Annotation of Natural Products unites the natural products chemistry, biological screening, data analytics and bioinformatic strengths of UTSW and UC Santa Cruz to generate a center for natural products research that can use innovative strategies to study the biological effects of botanicals and natural products. Our deliverables will orthogonal data sets that will allow predictions and validation of mechanism of action for libraries of botanicals and natural products. We intend for this to be a significant resource with long-term value for the botanical, natural product and biomedical research communities. Prosecution of this goal requires extensive interaction and collaboration within and among internal and external multidisciplinary teams. This includes integration of the UTSW and UCSC research teams, interaction with other CANPIT centers and ODS Botanical Centers, and meeting the data standards, information scale, and data sharing expectations of the CANPIT program. As such an administrative core is essential to 1) organize and maintain a framework for effective collaborative interaction within Center; 2) establish and maintain program oversight to enable compliance with metadata quality standards, public data release of data, and other NIH grants governance and reporting standards; and 3) facilitate monthly and yearly meetings of the scientific team and an external advisory board.

翻译后摘要：中心的高产量功能诠释的天然产品团结的自然 UTSW和UC Santa的产品化学、生物筛选、数据分析和生物信息学优势 克鲁兹创建一个天然产品研究中心，可以使用创新策略来研究 植物和天然产物的生物效应。我们的交付成果将正交数据集， 预测和验证植物和天然产物库的作用机制。我们打算通过 这是一个重要的资源与长期价值的植物，天然产品和生物医学研究 社区.实现这一目标需要在内部和内部之间进行广泛的互动与合作。 内部和外部多学科团队。这包括UTSW和UCSC研究的整合 团队，与其他CANPIT中心和ODS植物中心的互动，以及满足数据标准， 信息规模和CANPIT计划的数据共享期望。这样的行政核心是 必须1）组织和维护中心内部有效协作互动的框架; 2） 建立和维护计划监督，以确保符合元数据质量标准、公共数据 发布数据，以及其他NIH赠款管理和报告标准;以及3）促进每月和每年 科学小组和外部咨询委员会的会议。