MacMillan: Administrative Core; The Center for High-Throughput Functional Annotation of Natural Products Administrative Core (Macmillian)

摘要：高通量天然产物功能注释中心将天然产物 UTSW和UC Santa的产品化学、生物筛选、数据分析和生物信息学优势 克鲁兹将建立一个天然产品研究中心，可以使用创新策略来研究 植物和天然产品的生物学效应。我们的交付成果将正交数据集，从而使 植物和天然产物文库作用机制的预测和验证。我们打算 对于植物学、天然产物和生物医学研究来说，这是一种具有长期价值的重要资源 社区。要实现这一目标，需要在内部和之间进行广泛的互动和合作 内部和外部多学科团队。这包括UTSW和UCSC研究的整合 团队，与其他CANPIT中心和消耗臭氧层物质植物中心的互动，并满足数据标准， 信息规模，以及对CANPIT计划的数据共享期望。因此，管理核心是 对1)组织和维护中心内有效协作互动的框架至关重要；2) 建立和维护计划监督，以确保遵守元数据质量标准、公共数据 发布数据，以及其他NIH赠款治理和报告标准；以及3)促进每月和每年 科学小组和外部咨询委员会的会议。

Abstract: The Center for High-Throughput Functional Annotation of Natural Products unites the natural products chemistry, biological screening, data analytics and bioinformatic strengths of UTSW and UC Santa Cruz to generate a center for natural products research that can use innovative strategies to study the biological effects of botanicals and natural products. Our deliverables will orthogonal data sets that will allow predictions and validation of mechanism of action for libraries of botanicals and natural products. We intend for this to be a significant resource with long-term value for the botanical, natural product and biomedical research communities. Prosecution of this goal requires extensive interaction and collaboration within and among internal and external multidisciplinary teams. This includes integration of the UTSW and UCSC research teams, interaction with other CANPIT centers and ODS Botanical Centers, and meeting the data standards, information scale, and data sharing expectations of the CANPIT program. As such an administrative core is essential to 1) organize and maintain a framework for effective collaborative interaction within Center; 2) establish and maintain program oversight to enable compliance with metadata quality standards, public data release of data, and other NIH grants governance and reporting standards; and 3) facilitate monthly and yearly meetings of the scientific team and an external advisory board.