Requirement of hydrogen sulfide for the benefits of dietary sulfur amino acid restriction

 描述（由申请人提供）：该项目旨在确定一个驱动衰老的核心因素，以制定有针对性的干预措施，以延迟发病，甚至逆转衰老相关的病理。我的初步数据表明，热量限制（CR），一种经过验证的延长寿命的干预措施，刺激硫化氢气体的内源性产生，这是CR的抗应激益处所必需的。在这里，我们测试与年龄相关的内源性硫化氢产生的下降，如果它被延迟的一个特定的和更临床上有利的形式的饮食限制，蛋氨酸限制，作为一种手段，以增加代谢健身，抗应激和长寿。

 DESCRIPTION (provided by applicant): This project seeks to identify a central factor driving aging in order to develop targeted interventions to delay the onset or even reverse aging-related pathologies. My preliminary data demonstrate caloric restriction (CR), a proven intervention for increasing lifespan stimulates endogenous production of hydrogen sulfide gas and this is necessary for the stress resistance benefits of CR. Here, we test age related decline of endogenous hydrogen sulfide production and if it is delayed by a specific and more clinically favorable form of dietary restriction, methionine restriction, as a means to increase metabolic fitness, stress resistance and longevity.